| Long-term prognostic significance of coronary flow velocity reserve in patients with significant coronary artery disease not involving the left anterior descending coronary artery (results from the SZEGED study). | |
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MedLine Citation:
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PMID: 20486959 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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OBJECTIVE: Coronary flow velocity reserve (CFR) by pulsed Doppler echocardiography is a useful hemodynamic index to evaluate the coronary microcirculatory dysfunction in the left anterior descending coronary artery (LAD). The present study was designed to evaluate the long-term predictive value of CFR for mortality in patients with right (RC) and/or left circumflex coronary artery (CX) stenosis without epicardial LAD disease. METHODS: A total of 49 patients with significant RC and/or CX stenosis were enrolled in this prospective follow-up study. All patients had undergone coronary angiography demonstrating significant RC and/or CX stenosis without LAD disease and dipyridamole stress transoesophageal echocardiography as CFR measurement. RESULTS: The success rate of follow-up was 43 out of 49 (88%). During a mean follow-up of 97 +/- 29 months, 14 patients suffered cardiovascular deaths (12 sudden cardiac deaths and 2 strokes), and 1 patient died of pulmonal tumor. Patients who died during the follow-up had significantly lower CFR values (1.85 +/- 0.43 vs. 2.31 +/- 0.57, P < 0.05). Using ROC analysis, CFR <2.09 had the highest accuracy in predicting cardiovascular survival (sensitivity 80%, specificity 57%, area under the curve 73%, P = 0.003). The logistic regression model identified only CFR as an independent predictor of survival (hazard ratio [HR] 6.26, 95% CI of HR 1.23-19.61, P = 0.024). CONCLUSIONS: Long-term prognostic significance of CFR for the prediction of mortality has been demonstrated during a 9-year follow-up in patients with significant coronary artery disease not involving the LAD. |
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Authors:
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Attila Nemes; Erika Balázs; Szilvia Pintér; Miklós Csanády; Tamás Forster |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Echocardiography (Mount Kisco, N.Y.) Volume: 27 ISSN: 1540-8175 ISO Abbreviation: Echocardiography Publication Date: 2010 Mar |
Date Detail:
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Created Date: 2010-05-21 Completed Date: 2010-09-20 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 8511187 Medline TA: Echocardiography Country: United States |
Other Details:
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Languages: eng Pagination: 306-10 Citation Subset: IM |
Affiliation:
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Second Department of Medicine and Cardiology Center, Medical Faculty, Albert Szent-Györgyi Clinical Center, University of Szeged, H-6720 Szeged, Hungary. nemes@in2nd.szote.u-szeged.hu |
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| MeSH Terms | |
Descriptor/Qualifier:
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Aged Angiography Blood Flow Velocity Cardiomyopathies / physiopathology*, ultrasonography Coronary Artery Disease / mortality, physiopathology*, ultrasonography Coronary Circulation Coronary Vessel Anomalies / ultrasonography Coronary Vessels / physiopathology*, ultrasonography Echocardiography Female Follow-Up Studies Humans Male Multivariate Analysis Prognosis |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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