Document Detail

Long-term prognosis of adult patients with isolated congenital left ventricular aneurysm or diverticulum and abnormal electrocardiogram patterns.
MedLine Citation:
PMID:  22785433     Owner:  NLM     Status:  MEDLINE    
BACKGROUND:  Congenital left ventricular aneurysm (LVA) and diverticulum (LVD) are rare cardiac anomalies frequently associated with electrocardiogram (ECG) abnormalities. The aim of this study was to evaluate the long-term prognosis in such patients.
METHODS AND RESULTS:  A total of 108 patients with LVA or LVD having ECG-abnormalities were assessed. The patients were classified into 2 groups according to ECG abnormalities: a distinct ECG group (8 ECG patterns known to be frequently associated with LVA/LVD); and a control group (all other ECG abnormalities). The primary endpoint was a composite of cardiac death, rhythm disturbances, syncope, embolic events, and hospitalization for cardiovascular events. Mean patient age was 64±10 years; 45 (42%) were male; median follow-up (FU) was 50 months. The primary endpoint occurred in 12/27 patients from the distinct ECG group and in 15/81 patients in the control group (44% vs. 19%; P=0.01). Cardiac event rate per year (CER) was 1.8% vs. 0.8%, respectively. There were no cardiac deaths during FU. Symptoms (arrhythmia-related symptoms, syncope, and embolic events) at time of diagnosis increased the incidence of adverse events during FU (70% vs. 28%; P=0.05; CER 2.9% vs. 1.1%). Age ≥64 years, presence of LVD, gender, and location of the anomaly did not affect the incidence of adverse events.
CONCLUSIONS:  The incidence of adverse events in symptomatic patients with isolated LVA or LVD and distinct abnormal ECG patterns is increased during long-term FU. None of the present patients, however, experienced cardiac death. 
Marc-Alexander Ohlow; Bernward Lauer; Ulrich Lotze; Michele Brunelli; J Christoph Geller
Related Documents :
10418863 - The prevalence of cervical spondylolisthesis.
7133743 - Stenosis and movement of the cervical spine in cervical myelopathy.
6829653 - Hyperprolactinemia and headaches.
Publication Detail:
Type:  Journal Article     Date:  2012-06-30
Journal Detail:
Title:  Circulation journal : official journal of the Japanese Circulation Society     Volume:  76     ISSN:  1347-4820     ISO Abbreviation:  Circ. J.     Publication Date:  2012  
Date Detail:
Created Date:  2012-09-25     Completed Date:  2013-02-14     Revised Date:  2013-02-19    
Medline Journal Info:
Nlm Unique ID:  101137683     Medline TA:  Circ J     Country:  Japan    
Other Details:
Languages:  eng     Pagination:  2465-70     Citation Subset:  IM    
Department of Cardiology, Zentralklinik Bad Berka, Robert-Koch-Allee 9, 99437 Bad Berka, Germany.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Disease-Free Survival
Diverticulum* / mortality,  physiopathology,  radiography
Heart Aneurysm* / mortality,  physiopathology,  radiography
Middle Aged
Survival Rate
Time Factors
Comment In:
Circ J. 2012;77(1):275   [PMID:  23131758 ]
Circ J. 2012;77(1):276   [PMID:  23131760 ]

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  Improving the calculation of electron paramagnetic resonance hyperfine coupling tensors for d-block ...
Next Document:  Efficacy and safety of periprocedural dabigatran in patients undergoing catheter ablation of atrial ...