| The long-term outcomes of the second generation of familial nonmedullary thyroid carcinoma are more aggressive than sporadic cases. | |
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MedLine Citation:
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PMID: 22280228 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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BACKGROUND: Familial nonmedullary thyroid carcinoma (FNMTC) is frequently detected, but the prevalence or the aggressiveness of FNMTC is still unclear. We aimed to investigate the prevalence, clinical characteristics, and prognosis of FNMTC. METHODS: This study included 3056 nonmedullary thyroid carcinoma (NMTC) patients who were pathologically confirmed to exhibit differentiated thyroid carcinoma from January 1962 through March 2010. The duration of follow-up was 6.2±6.2 years. RESULTS: The prevalence of FNMTC was 9.6%; 37.9% of the FNMTC patients exhibited a parent-offspring relationship, and 62.1% exhibited a sibling relationship. FNMTC was smaller in tumor size (1.2±0.9 vs. 1.4±1.1 cm) and more multifocal (33.6% vs. 27.0%) than sporadic cases. FNMTC presented higher recurrence rates (29.5% vs. 19.8%) and shorter recurrence-free survival than sporadic NMTC (p=0.046). When we compared sporadic NMTC with parent-offspring or sibling FNMTC separately, parent-offspring FNMTC was more multifocal (39.3% vs. 27.0%), while sibling FNMTC was more prevalent in female patients (89.6% vs. 82.5%) and presented smaller tumors (1.2±0.8 vs. 1.4±1.1 cm) than sporadic NMTC. The recurrence rate was higher than that of sporadic NMTC in parent-offspring FNMTC (35.6% vs. 19.8%) but not in sibling FNMTC. Among the 123 parent-offspring FNMTC cases, the second generation exhibited an earlier age at the diagnosis (38±11 vs. 57±11 years), more extrathyroidal invasion (57.8% vs. 29.4%), a higher recurrence rate (50.0% vs. 19.0%), and shorter recurrence-free survival (p=0.015) than the first generation. CONCLUSION: FNMTC was found to have a very high prevalence in our population. Parent-offspring FNMTC demonstrated higher recurrence than sporadic NMTC; specifically, the second generation of parent-offspring FNMTC cases exhibited more aggressive clinical characteristics than the first generation. |
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Authors:
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Young Joo Park; Hwa Young Ahn; Hoon Sung Choi; Kyung Won Kim; Do Joon Park; Bo Youn Cho |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't Date: 2012-01-26 |
Journal Detail:
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Title: Thyroid : official journal of the American Thyroid Association Volume: 22 ISSN: 1557-9077 ISO Abbreviation: Thyroid Publication Date: 2012 Apr |
Date Detail:
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Created Date: 2012-03-30 Completed Date: 2012-07-26 Revised Date: 2013-04-01 |
Medline Journal Info:
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Nlm Unique ID: 9104317 Medline TA: Thyroid Country: United States |
Other Details:
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Languages: eng Pagination: 356-62 Citation Subset: IM |
Affiliation:
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Department of Internal Medicine, College of Medicine, Seoul National University, Seoul, Republic of Korea. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adult Age of Onset Aged Carcinoma, Papillary / epidemiology, genetics*, pathology* Disease-Free Survival Female Follow-Up Studies Humans Male Middle Aged Neoplasm Metastasis / genetics Neoplasm Recurrence, Local Neoplasm Staging Republic of Korea / epidemiology Sex Factors Thyroid Neoplasms / epidemiology, genetics*, pathology* Thyroiditis / complications |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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