Document Detail

Long-term outcome of patients with obscure gastrointestinal bleeding investigated by double-balloon endoscopy.
MedLine Citation:
PMID:  19879968     Owner:  NLM     Status:  MEDLINE    
BACKGROUND & AIMS: It is often difficult to determine the cause of obscure gastrointestinal bleeding (OGIB). We evaluated the diagnostic yield and long-term outcome of patients with OGIB by using double-balloon endoscopy (DBE).
METHODS: In this large, retrospective cohort study, DBE was performed in 200 consecutive patients with OGIB. Follow-up data were available from 151 patients for 29.7 months (range, 6-78 months), and clinical outcome was assessed.
RESULTS: DBE detected bleeding sources in 155 of 200 patients (77.5%). The most frequent source detected was small intestine ulcers/erosions (64 patients). Patients who underwent DBE within 1 month after the last episode of overt bleeding had a better yield of positive findings than those who did not (84%, 107/128 patients vs 57%, 24/42; P = .002). The overall rate of control of OGIB was 64% (97/151 patients). Patients with vascular lesions of the small intestine had a significantly lower rate of control of OGIB than those with other small intestine lesions (40%, 12/30 patients vs 74%, 52/70; P = .001). A requirement for a large transfusion before DBE (P = .012), multiple lesions (P = .010), and suspicious (not definite) lesions (P = .038) each significantly increased the likelihood of overt rebleeding in patients with vascular lesions of the small intestine.
CONCLUSIONS: DBE is useful for the diagnosis of patients with OGIB and should be performed as soon as possible after overt OGIB. Patients with vascular lesions of the small intestine should be followed with particular care.
Satoshi Shinozaki; Hironori Yamamoto; Tomonori Yano; Keijiro Sunada; Tomohiko Miyata; Yoshikazu Hayashi; Masayuki Arashiro; Kentaro Sugano
Related Documents :
16111958 - Performance of antegrade double-balloon enteroscopy: comparison with push enteroscopy.
14638348 - Overlapping upper and lower gastrointestinal symptoms in irritable bowel syndrome patie...
11711768 - A controlled, double-blind, randomized study on the efficacy of lactobacillus plantarum...
21453648 - Audiometric profile in patients with chronic renal failure.
17938368 - Hemiparkinsonism-hemiatrophy syndrome.
20948118 - Adenosine deaminase activity in serum and lymphocytes of multibacillary leprosy patients.
Publication Detail:
Type:  Journal Article     Date:  2009-10-30
Journal Detail:
Title:  Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association     Volume:  8     ISSN:  1542-7714     ISO Abbreviation:  Clin. Gastroenterol. Hepatol.     Publication Date:  2010 Feb 
Date Detail:
Created Date:  2010-02-15     Completed Date:  2010-04-21     Revised Date:  2011-02-02    
Medline Journal Info:
Nlm Unique ID:  101160775     Medline TA:  Clin Gastroenterol Hepatol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  151-8     Citation Subset:  IM    
Copyright Information:
Copyright 2010 AGA Institute. Published by Elsevier Inc. All rights reserved.
Department of Medicine, Division of Gastroenterology, Jichi Medical University, Tochigi, Japan.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Aged, 80 and over
Cohort Studies
Endoscopy, Gastrointestinal / methods*
Follow-Up Studies
Gastrointestinal Hemorrhage / diagnosis*,  surgery*
Middle Aged
Retrospective Studies
Treatment Outcome
Young Adult
Comment In:
Gastroenterology. 2010 Dec;139(6):2215-7; discussion 2217   [PMID:  20970448 ]
Endoscopy. 2011 Jan;43(1):38-41   [PMID:  21108176 ]

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  Symptoms and Tests for IBS: Diagnosing a Complex Disorder.
Next Document:  Nuclear Medicine Hepatobiliary Imaging.