Document Detail


The Long-Term Outcome of Hepatic Artery Thrombosis After Liver Transplantation in Children: Role of Urgent Revascularization.
MedLine Citation:
PMID:  22390346     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
Hepatic artery thrombosis (HAT), one of the most severe complications of pediatric orthotopic liver transplantation (OLT), often compromises graft and/or child survival. Of 590 OLT performed in 516 children over a 20-year period, 45 were complicated by early HAT, during the first 2 weeks after transplantation. Systematic Doppler ultrasonographic detection of HAT allowed successful surgical revascularization in 19 instances, resulting in a 20-year graft survival rate of 77% versus 24% of cases when revascularization was not attempted or failed. A combination of surgical emergency revascularization, biliary interventional radiology, biliary surgery and/or retransplantation resulted in an 80% 20-year patient survival rate, identical to that of transplanted children who did not experience early HAT. The majority of long-term survivors with their initial graft had normal liver tests, no biliary dilation on ultrasonography and minimal or moderate fibrosis on liver histology. A failed attempt at revascularization did not significantly alter patient survival. Despite these encouraging results, for the children and their parents to overcome the entire process in terms of reoperations, repeated radiological interventions, number of hospitalizations and emotional stress, remains an ordeal of such magnitude that it justifies renewed efforts to progress in the prevention of this complication.
Authors:
O Ackermann; S Branchereau; S Franchi-Abella; D Pariente; L Chevret; D Debray; E Jacquemin; F Gauthier; C Hill; O Bernard
Related Documents :
22416256 - Early il-10 production is essential for syngeneic graft acceptance.
7781646 - Effect of allopurinol, folinic acid, sod and cyclosporine a on ischemic liver regenerat...
11330546 - The effect of cd28/b7 blockade on alloreactive t and b cells after liver cell transplan...
11453536 - A novel approach to ex vivo gene therapy for familial hypercholesterolemia using human ...
16317886 - Auto-transplantation in the restorative management of traumatized anterior teeth: a cas...
17092326 - Transient renal tubulopathy in a racing greyhound.
Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2012-3-5
Journal Detail:
Title:  American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons     Volume:  -     ISSN:  1600-6143     ISO Abbreviation:  -     Publication Date:  2012 Mar 
Date Detail:
Created Date:  2012-3-6     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  100968638     Medline TA:  Am J Transplant     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Copyright Information:
© Copyright 2012 The American Society of Transplantation and the American Society of Transplant Surgeons.
Affiliation:
Hépatologie Pédiatrique, Hôpital Bicêtre, APHP, Assistance Publique - Hôpitaux de Paris, France and Université Paris Sud 11, Paris, France Chirurgie Pédiatrique, Hôpital Bicêtre, Assistance Publique - Hôpitaux de Paris, France and Université Paris Sud 11, Paris, France Radiologie Pédiatrique, Hôpital Bicêtre, Assistance Publique - Hôpitaux de Paris, France Réanimation Pédiatrique, Hôpital Bicêtre, Assistance Publique - Hôpitaux de Paris and Université Paris Sud 11, Paris, France Biostatistique et Epidemiologie, Institut Gustave Roussy, Villejuif, France.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  The Temperature Dependence of Thermal Boundary Resistances Between Multiwall Carbon Nanotubes and So...
Next Document:  Upon a Failure to Equal Entry and Exit Wounds: A Possible Case of Tandem Bullets in View of the Lite...