Document Detail


Long-Term Outcome of Anterior Thalamic Nucleus Stimulation for Intractable Epilepsy.
MedLine Citation:
PMID:  22922474     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
Background: Many patients with epilepsy have persistent seizures despite treatment with maximal antiepileptic drug therapy and are not candidates for resective brain surgery. Objectives: We investigated the effectiveness of seizure reduction after anterior thalamic nucleus (ATN) stimulation in patients with intractable epilepsy undergoing deep brain stimulation (DBS) of the thalamus. Methods: Patients included in this study had poorly controlled seizures, despite anticonvulsant medication, and were not candidates for surgical resection of an identifiable seizure focus. Fifteen patients with medically refractory epilepsy underwent the placement of bilateral DBS electrodes in the anterior thalamus. The seizure frequency was monitored and compared with the preimplantation baseline. Results: The treatment demonstrated a statistically significant decrease in the seizure frequency, with a mean reduction of 70.4% (mean follow-up, 27 months). Two of the patients had a remarkable reduction of seizure frequency. Conclusion: It seems to be important that the short-term outcome of ATN DBS reflects the long-term outcome directly. The correlation between the seizure type, characteristics and anticonvulsant effects of ATN DBS did not exhibit significance because of the small number of cases. Therefore, a longer-term follow-up with a larger group of patients is required to fully evaluate the safety and effectiveness of this treatment modality.
Authors:
Kyung Jin Lee; Young Min Shon; Chul Bum Cho
Related Documents :
20630684 - A design modification to minimize tilting of an inferior vena cava filter does not deli...
12379064 - Ximelagatran versus warfarin for the prevention of venous thromboembolism after total k...
15284544 - Current trends in vena caval filtration with the introduction of a retrievable filter a...
12621574 - Complications of minor cutaneous surgery in patients under anticoagulant treatment.
2769844 - Extracorporeal shock wave lithotripsy treatment of calculi in horseshoe kidneys.
21337584 - Comparison of three types of preparations for abdominal sonography.
Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2012-8-23
Journal Detail:
Title:  Stereotactic and functional neurosurgery     Volume:  90     ISSN:  1423-0372     ISO Abbreviation:  Stereotact Funct Neurosurg     Publication Date:  2012 Aug 
Date Detail:
Created Date:  2012-8-27     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8902881     Medline TA:  Stereotact Funct Neurosurg     Country:  -    
Other Details:
Languages:  ENG     Pagination:  379-385     Citation Subset:  -    
Copyright Information:
Copyright © 2012 S. Karger AG, Basel.
Affiliation:
Department of Neurosurgery, College of Medicine, Yeouido Saint Mary's Hospital, Catholic University of Korea, Seoul, South Korea.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  Effect of Photodynamic Antimicrobial Chemotherapy on in vitro and in situ Biofilms.
Next Document:  A xenon recirculating ventilator for the newborn piglet: developing clinical applications of xenon f...