Document Detail


Long-term outcome of anterior thalamic nucleus stimulation for intractable epilepsy.
MedLine Citation:
PMID:  22922474     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
BACKGROUND: Many patients with epilepsy have persistent seizures despite treatment with maximal antiepileptic drug therapy and are not candidates for resective brain surgery.
OBJECTIVES: We investigated the effectiveness of seizure reduction after anterior thalamic nucleus (ATN) stimulation in patients with intractable epilepsy undergoing deep brain stimulation (DBS) of the thalamus.
METHODS: Patients included in this study had poorly controlled seizures, despite anticonvulsant medication, and were not candidates for surgical resection of an identifiable seizure focus. Fifteen patients with medically refractory epilepsy underwent the placement of bilateral DBS electrodes in the anterior thalamus. The seizure frequency was monitored and compared with the preimplantation baseline.
RESULTS: The treatment demonstrated a statistically significant decrease in the seizure frequency, with a mean reduction of 70.4% (mean follow-up, 27 months). Two of the patients had a remarkable reduction of seizure frequency.
CONCLUSION: It seems to be important that the short-term outcome of ATN DBS reflects the long-term outcome directly. The correlation between the seizure type, characteristics and anticonvulsant effects of ATN DBS did not exhibit significance because of the small number of cases. Therefore, a longer-term follow-up with a larger group of patients is required to fully evaluate the safety and effectiveness of this treatment modality.
Authors:
Kyung Jin Lee; Young Min Shon; Chul Bum Cho
Related Documents :
18616644 - Proton pump inhibitors reduce the long-term risk of recurrent upper gastrointestinal bl...
23140034 - Outcomes after temporal lobectomy for temporal lobe epilepsy with hippocampal sclerosis.
16164494 - Bleeding complications in patients on celecoxib and warfarin.
17337944 - Management plan of post-angiography false aneurysms of the groin.
24518634 - Early syphilis: serological treatment response to doxycycline/tetracycline versus benza...
23354104 - The aospine north america geriatric odontoid fracture mortality study: a retrospective ...
Publication Detail:
Type:  Clinical Trial; Journal Article; Research Support, Non-U.S. Gov't     Date:  2012-08-23
Journal Detail:
Title:  Stereotactic and functional neurosurgery     Volume:  90     ISSN:  1423-0372     ISO Abbreviation:  Stereotact Funct Neurosurg     Publication Date:  2012  
Date Detail:
Created Date:  2012-12-11     Completed Date:  2013-05-22     Revised Date:  2014-07-31    
Medline Journal Info:
Nlm Unique ID:  8902881     Medline TA:  Stereotact Funct Neurosurg     Country:  Switzerland    
Other Details:
Languages:  eng     Pagination:  379-85     Citation Subset:  IM    
Copyright Information:
Copyright © 2012 S. Karger AG, Basel.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:
Adolescent
Adult
Anterior Thalamic Nuclei / physiology*
Anticonvulsants / therapeutic use
Deep Brain Stimulation / methods*
Drug Resistance
Electroencephalography
Epilepsy / diagnosis,  drug therapy,  therapy*
Female
Follow-Up Studies
Humans
Magnetic Resonance Imaging
Male
Middle Aged
Neuronavigation / methods
Time
Treatment Outcome
Young Adult
Chemical
Reg. No./Substance:
0/Anticonvulsants

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  Effect of Photodynamic Antimicrobial Chemotherapy on in vitro and in situ Biofilms.
Next Document:  A xenon recirculating ventilator for the newborn piglet: developing clinical applications of xenon f...