| Long Term Omega-3 Polyunsaturated Fatty Acid Supplementation Reduces the Recurrence of Persistent Atrial Fibrillation after Electrical Cardioversion. | |
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MedLine Citation:
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PMID: 22120130 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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BACKGROUND: Persistent atrial fibrillation (AF) is associated with a high risk of recurrence after electrical cardioversion. OBJECTIVE: We examined if long-term supplementation with omega-3 polyunsaturated fatty acids in fish oils commenced > 1 month prior to electrical cardioversion and continued thereafter reduces the recurrence of persistent AF. METHODS: This was an open label, randomized study of patients with documented persistent AF > 1-month duration. Participants were assigned to control group or omega-3 group (6g/d fish oil) and underwent cardioversion 1 month later. Concurrent anti-arrhythmic use of sotalol or amiodarone was permitted. Fish oil was continued till return of persistent AF or a maximum of 1 year. Intention-to-treat analysis was performed for the primary endpoint defined as the recurrence of persistent AF. RESULTS: Mean duration of fish oil intake was 56 days pre-cardioversion and total of 242 days in follow up. Eicosapentaenoic acid and docosahexaenoic acid, the active component of fish oils were 1.8 fold and 2.1 fold higher respectively in the omega-3 group compared to controls at the time of cardioversion (p<0.001). At 90 days, 38.5% of omega-3 patients had AF recurrence compared to 77.5% of controls (hazard ratio omega-3 vs. control: 0.38, 95% confidence interval 0.27-0.56, p<0.001). Omega-3 intake was associated with a significant reduction in AF recurrence with or without concurrent anti-arrhythmic drugs. CONCLUSIONS: Omega-3 polyunsaturated fatty acid supplementation commenced > 1 month prior to electrical cardioversion and continued thereafter reduces the recurrence of persistent AF. Randomized trials on long term fish oil supplementation are needed to confirm these findings. |
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Authors:
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Saurabh Kumar; Fiona Sutherland; Joseph B Morton; Geoffrey Lee; John Morgan; James Wong; David E Eccleston; John Voukelatos; Manohar L Garg; Paul B Sparks |
Publication Detail:
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Type: JOURNAL ARTICLE Date: 2011-11-22 |
Journal Detail:
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Title: Heart rhythm : the official journal of the Heart Rhythm Society Volume: - ISSN: 1556-3871 ISO Abbreviation: - Publication Date: 2011 Nov |
Date Detail:
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Created Date: 2011-11-28 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 101200317 Medline TA: Heart Rhythm Country: - |
Other Details:
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Languages: ENG Pagination: - Citation Subset: - |
Copyright Information:
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Copyright © 2011. Published by Elsevier Inc. |
Affiliation:
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Department of Cardiology, The Royal Melbourne Hospital, Parkville, Victoria, Australia; Department of Medicine, University of Melbourne, Parkville, Victoria, Australia. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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