Document Detail


Long-Term Nutrition and Predictors of Growth and Weight Gain Following Pediatric Intestinal Transplantation.
MedLine Citation:
PMID:  21869734     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
BACKGROUND.: Advances in intestinal transplantation (ITx) have resulted in improved survival and the opportunity to examine nutritional outcomes. The aim of this study was to describe detailed, long-term nutritional results and identify positive predictors of growth and weight gain following pediatric ITx. METHODS.: A single-center retrospective, Institutional Review Board-approved review of a prospective database was conducted. Inclusion criteria were ITx recipients 18 years or younger with survival of 6 months or more. Outcomes included anthropometric measurements and biochemical markers at 6, 12, 24, 36, and 48 months post-ITx. More than 25 ITx-related variables were analyzed as potential predictors of growth and weight gain. Statistical analysis was performed using chi-square test, t test, and analysis of variance. RESULTS.: Between November 1991 and April 2007, 50 children received 55 ITx; 33 patients met eligibility criteria. Median age at ITx was 2.2 years, follow-up time was 3.8 years, and time from ITx to cessation of total parenteral nutrition was 31 days. The most common micronutrient deficiencies post-ITx were zinc, iron, and copper. Serum protein levels improved significantly over time. Weight gain occurred within 6 months and vertical growth within 12 months, although limited catch-up growth was seen. Early predictors of weight gain and growth included shorter hospitalization and absence of rejection. Long-term predictors were low steroid dosage, infrequent hospitalization, and the use of peptide-based formulas. CONCLUSIONS.: This represents one of the largest and most comprehensive long-term studies on nutritional outcomes in pediatric ITx. Overall, positive growth and weight gain were seen as were micronutrient deficiencies. Numerous long-term nutritional challenges exist which require a multidisciplinary approach and future prospective studies.
Authors:
Robert S Venick; Laura J Wozniak; Joanie Colangelo; Patty Beckwith; Laurie Reyen; Yvonne A Esmailian; Sue V McDiarmid; Jorge H Vargas; Marvin E Ament; Ronald W Busuttil; Douglas G Farmer
Related Documents :
10190914 - Comparison of a beta-lactam alone versus beta-lactam and an aminoglycoside for pulmonar...
7661494 - Treatment of shigellosis: iv. cefixime is ineffective in shigellosis in adults.
2714094 - Factors influencing predilection and outcome in bacterial keratitis.
2185964 - Recurrent respiratory infections in childhood: experience with a bacterial extract plus...
24696074 - The attenuation of lung ischemia reperfusion injury by oxymatrine.
2491454 - A multicentre, randomized, double-blind study comparing nocte famotidine or ranitidine ...
Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2011-8-24
Journal Detail:
Title:  Transplantation     Volume:  -     ISSN:  1534-6080     ISO Abbreviation:  -     Publication Date:  2011 Aug 
Date Detail:
Created Date:  2011-8-26     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0132144     Medline TA:  Transplantation     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Affiliation:
1 Pediatric Gastroenterology, Hepatology & Nutrition, Mattel Children's Hospital at UCLA, Los Angeles, CA. 2 Surgery, Dumont-UCLA Transplant Center, David Geffen School of Medicine at UCLA, Los Angeles, CA. 3 Nutrition, UCLA Medical Center, David Geffen School of Medicine at UCLA, Los Angeles, CA. 4 Nursing, UCLA Medical Center, David Geffen School of Medicine at UCLA, Los Angeles, CA.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  Gene set analysis of purine and pyrimidine antimetabolites cancer therapies.
Next Document:  Acute-on-Chronic Liver Failure Before Liver Transplantation: Impact on Posttransplant Outcomes.