| Long-term impact of routinely detected early and late incomplete stent apposition: an integrated intravascular ultrasound analysis of the TAXUS IV, V, and VI and TAXUS ATLAS workhorse, long lesion, and direct stent studies. | |
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MedLine Citation:
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PMID: 20488404 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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OBJECTIVES: We sought to determine the 2-year impact of early and late-acquired incomplete stent apposition (ISA) on clinical events. BACKGROUND: The late clinical impact of early or late-acquired ISA in bare-metal stents (BMS) and TAXUS stents (Boston Scientific, Natick, Massachusetts) is debatable. METHODS: We evaluated 1,580 patients enrolled in the intravascular ultrasound (IVUS) substudies of TAXUS IV, V, VI and TAXUS-ATLAS WH, LL, and DS trials. RESULTS: There were 96 cases of early ISA in 26 (7.2%) BMS patients, 35 (9.7%) TAXUS Express patients (p = 0.28 vs. BMS), and 35 (7.3%) TAXUS Liberté patients (p = 0.21 vs. TAXUS Express, and p = 1.00 vs. BMS). Major adverse cardiovascular events were similar at 9 months in patients with early ISA versus control subjects with no ISA for BMS (3.8% vs. 15.2%, p = 0.13) and for TAXUS (11.6% vs. 8.8%, p = 0.45). There was no impact of early ISA on stent thrombosis. At 9-month follow-up, there were 36 cases of late-acquired ISA in 7 (2.7%) BMS patients, 17 (3.1%) patients with TAXUS slow-release (TAXUS Express or TAXUS Liberté), and 12 (15.4%) patients receiving TAXUS moderate-release. Over 2 ensuing years, major adverse cardiovascular events were similar in patients with late-acquired ISA versus control subjects with no ISA for BMS (14.3% vs. 7.9%, p = 0.54), TAXUS (overall, 8.3% vs. 8.1% p = 0.87), or TAXUS slow-release formulation (0% vs. 7.9%, p = 0.28). There was no impact of late-acquired ISA on stent thrombosis. CONCLUSIONS: Neither routinely detected acute ISA nor routinely detected late-acquired ISA in BMS or TAXUS patients was associated with adverse clinical events over long-term follow-up. |
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Authors:
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Daniel H Steinberg; Gary S Mintz; Lazar Mandinov; Alan Yu; Steven G Ellis; Eberhard Grube; Keith D Dawkins; John Ormiston; Mark A Turco; Gregg W Stone; Neil J Weissman |
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Publication Detail:
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Type: Journal Article; Multicenter Study; Randomized Controlled Trial |
Journal Detail:
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Title: JACC. Cardiovascular interventions Volume: 3 ISSN: 1876-7605 ISO Abbreviation: JACC Cardiovasc Interv Publication Date: 2010 May |
Date Detail:
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Created Date: 2010-05-21 Completed Date: 2010-08-30 Revised Date: 2012-08-29 |
Medline Journal Info:
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Nlm Unique ID: 101467004 Medline TA: JACC Cardiovasc Interv Country: United States |
Other Details:
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Languages: eng Pagination: 486-94 Citation Subset: IM |
Copyright Information:
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Copyright 2010 American College of Cardiology Foundation. Published by Elsevier Inc. All rights reserved. |
Affiliation:
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Medical University of South Carolina, Charleston, South Carolina 29425, USA. steinbe@musc.edu |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Aged Angioplasty, Balloon, Coronary / adverse effects, instrumentation* Cardiovascular Agents / administration & dosage* Cardiovascular Diseases / etiology, radiography, ultrasonography* Coronary Angiography Coronary Restenosis / etiology, ultrasonography Double-Blind Method Drug-Eluting Stents* Female Humans Kaplan-Meier Estimate Male Metals Middle Aged Paclitaxel / administration & dosage* Prospective Studies Prosthesis Design Stents* Thrombosis / etiology, ultrasonography Time Factors Treatment Outcome Ultrasonography, Interventional* |
| Chemical | |
Reg. No./Substance:
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0/Cardiovascular Agents; 0/Metals; 33069-62-4/Paclitaxel |
| Comments/Corrections | |
Comment In:
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JACC Cardiovasc Interv. 2010 May;3(5):495-7
[PMID:
20488405
]
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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