Document Detail

Long-term impact of neonatal injury in male and female rats: Sex differences, mechanisms and clinical implications.
MedLine Citation:
PMID:  20144647     Owner:  NLM     Status:  MEDLINE    
Over the last several decades, the relative contribution of early life events to individual disease susceptibility has been explored extensively. Only fairly recently, however, has it become evident that abnormal or excessive nociceptive activity experienced during the perinatal period may permanently alter the normal development of the CNS and influence future responses to somatosensory input. Given the significant rise in the number of premature infants receiving high-technology intensive care over the last 20 years, ex-preterm neonates may be exceedingly vulnerable to the long-term effects of repeated invasive interventions. The present review summarizes available clinical and laboratory findings on the lasting impact of exposure to noxious stimulation during early development, with a focus on the structural and functional alterations in nociceptive circuits, and its sexually dimorphic impact.
Jamie L LaPrairie; Anne Z Murphy
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.; Review     Date:  2010-02-06
Journal Detail:
Title:  Frontiers in neuroendocrinology     Volume:  31     ISSN:  1095-6808     ISO Abbreviation:  Front Neuroendocrinol     Publication Date:  2010 Apr 
Date Detail:
Created Date:  2010-04-05     Completed Date:  2010-06-18     Revised Date:  2014-09-13    
Medline Journal Info:
Nlm Unique ID:  7513292     Medline TA:  Front Neuroendocrinol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  193-202     Citation Subset:  IM    
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MeSH Terms
Animals, Newborn
Disease Models, Animal
Infant, Newborn
Infant, Premature*
Intensive Care, Neonatal
Pain Threshold*
Sex Characteristics
Grant Support
AR49555/AR/NIAMS NIH HHS; DA16272/DA/NIDA NIH HHS; P50 AR049555/AR/NIAMS NIH HHS; P50 AR049555-010001/AR/NIAMS NIH HHS; P50 AR049555-02/AR/NIAMS NIH HHS; P50 AR049555-03/AR/NIAMS NIH HHS; P50 AR049555-03S1/AR/NIAMS NIH HHS; P50 AR049555-04/AR/NIAMS NIH HHS; P50 AR049555-05/AR/NIAMS NIH HHS; R01 DA016272/DA/NIDA NIH HHS; R01 DA016272-01/DA/NIDA NIH HHS; R01 DA016272-02/DA/NIDA NIH HHS; R01 DA016272-03/DA/NIDA NIH HHS; R01 DA016272-04/DA/NIDA NIH HHS; R01 DA016272-05/DA/NIDA NIH HHS

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