| Long-term impact of neonatal injury in male and female rats: Sex differences, mechanisms and clinical implications. | |
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MedLine Citation:
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PMID: 20144647 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Over the last several decades, the relative contribution of early life events to individual disease susceptibility has been explored extensively. Only fairly recently, however, has it become evident that abnormal or excessive nociceptive activity experienced during the perinatal period may permanently alter the normal development of the CNS and influence future responses to somatosensory input. Given the significant rise in the number of premature infants receiving high-technology intensive care over the last 20 years, ex-preterm neonates may be exceedingly vulnerable to the long-term effects of repeated invasive interventions. The present review summarizes available clinical and laboratory findings on the lasting impact of exposure to noxious stimulation during early development, with a focus on the structural and functional alterations in nociceptive circuits, and its sexually dimorphic impact. |
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Authors:
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Jamie L LaPrairie; Anne Z Murphy |
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Publication Detail:
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Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.; Review Date: 2010-02-06 |
Journal Detail:
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Title: Frontiers in neuroendocrinology Volume: 31 ISSN: 1095-6808 ISO Abbreviation: Front Neuroendocrinol Publication Date: 2010 Apr |
Date Detail:
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Created Date: 2010-04-05 Completed Date: 2010-06-18 Revised Date: 2011-07-27 |
Medline Journal Info:
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Nlm Unique ID: 7513292 Medline TA: Front Neuroendocrinol Country: United States |
Other Details:
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Languages: eng Pagination: 193-202 Citation Subset: IM |
Affiliation:
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Neuroscience Institute, Georgia State University, 38 Peachtree Center Ave, 806 GCB, Atlanta, GA 30303, USA. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Analgesia Animals Animals, Newborn Disease Models, Animal Female Humans Infant, Newborn Infant, Premature* Intensive Care, Neonatal Male Pain Threshold* Rats Sex Characteristics |
| Grant Support | |
ID/Acronym/Agency:
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AR49555/AR/NIAMS NIH HHS; DA16272/DA/NIDA NIH HHS; P50 AR049555-010001/AR/NIAMS NIH HHS; P50 AR049555-02/AR/NIAMS NIH HHS; P50 AR049555-03/AR/NIAMS NIH HHS; P50 AR049555-03S1/AR/NIAMS NIH HHS; P50 AR049555-04/AR/NIAMS NIH HHS; P50 AR049555-05/AR/NIAMS NIH HHS; R01 DA016272-01/DA/NIDA NIH HHS; R01 DA016272-02/DA/NIDA NIH HHS; R01 DA016272-03/DA/NIDA NIH HHS; R01 DA016272-04/DA/NIDA NIH HHS; R01 DA016272-05/DA/NIDA NIH HHS |
| Comments/Corrections | |
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