| Long-Term Impact of GH Treatment during Childhood on Body Composition and Fat Distribution in Young Adults Born SGA. | |
| | |
MedLine Citation:
|
PMID: 21917862 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
|
Context:GH treatment of short children born small for gestational age (SGA) results in a decline in fat mass (FM) and an increase in lean body mass (LBM). It is, however, unknown whether these changes persist into adulthood.Objective:Our objective was to assess the long-term impact of GH treatment during childhood on body composition and fat distribution.Patients and Design:A total of 377 young adults participated in this cross-sectional study: 59 previously GH-treated young SGA adults compared to 52 untreated SGA adults with short stature (SGA-S), 161 SGA adults with spontaneous catch-up growth (SGA-CU), and 105 healthy normal-statured controls born appropriate for gestational age (AGA).Outcome Measures:Body composition and fat distribution were determined by dual-energy x-ray absorptiometry.Results:Mean (sd) duration of GH treatment was 7.7 (2.4) yr and period after discontinuation 6.8 (1.8) yr. FM, fat distribution, and LBM of GH-treated SGA adults were not significantly different from that of untreated SGA-S adults. GH-treated SGA adults also had a similar FM and fat distribution as SGA-CU adults but a lower LBM. All SGA subgroups had a lower LBM and tended to have a higher FM than healthy AGA controls.Conclusion:Body composition and fat distribution of previously GH-treated SGA adults was similar to that of untreated SGA-S adults. GH-induced catch-up growth has no unfavorable effect on FM and fat distribution compared with spontaneous catch-up growth. However, our study shows that SGA adults in general may have a different body composition than healthy AGA controls. |
| | |
Authors:
|
P E Breukhoven; G F Kerkhof; M van Dijk; A C S Hokken-Koelega |
Publication Detail:
|
Type: JOURNAL ARTICLE Date: 2011-9-14 |
Journal Detail:
|
Title: The Journal of clinical endocrinology and metabolism Volume: - ISSN: 1945-7197 ISO Abbreviation: - Publication Date: 2011 Sep |
Date Detail:
|
Created Date: 2011-9-15 Completed Date: - Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 0375362 Medline TA: J Clin Endocrinol Metab Country: - |
Other Details:
|
Languages: ENG Pagination: - Citation Subset: - |
Affiliation:
|
Department of Paediatrics, Subdivision of Endocrinology, Erasmus University Medical Center/Sophia Children's Hospital, 3015 GJ Rotterdam, The Netherlands. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
|
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Urine steroid metabolomics as a biomarker tool for detecting malignancy in adrenal tumors.
Next Document: Lower Free Thyroxin Associates with a Less Favorable Metabolic Phenotype in Healthy Pregnant Women.