Document Detail


Long-term functional engraftment of mesenchymal progenitor cells in a mouse model of accelerated aging.
MedLine Citation:
PMID:  23193076     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Age-related osteoporosis is characterized by a decrease in bone-forming capacity mediated by defects in the number and function of osteoblasts. An important cellular mechanism that may in part explain osteoblast dysfunction that occurs with aging is senescence of mesenchymal progenitor cells (MPCs). In the telomere-based Wrn(-/-) Terc(-/-) model of accelerated aging, the osteoporotic phenotype of these mice is also associated with a major decline in MPC differentiation into osteoblasts. To investigate the role of MPC aging as a cell-autonomous mechanism in senile bone loss, transplantation of young wild-type whole bone marrow into Wrn(-/-) Terc(-/-) mutants was performed and the ability of engrafted cells to differentiate into cells of the osteoblast lineage was assessed. We found that whole bone marrow transplantation in Wrn(-/-) Terc(-/-) mice resulted in functional engraftment of MPCs up to 42 weeks, which was accompanied by a survival advantage as well as delays in microarchitectural features of skeletal aging.
Authors:
Lakshman Singh; Tracy A Brennan; Jung-Hoon Kim; Kevin P Egan; Emily A McMillan; Qijun Chen; Kurt D Hankenson; Yi Zhang; Stephen G Emerson; F Brad Johnson; Robert J Pignolo
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Stem cells (Dayton, Ohio)     Volume:  31     ISSN:  1549-4918     ISO Abbreviation:  Stem Cells     Publication Date:  2013 Mar 
Date Detail:
Created Date:  2013-02-26     Completed Date:  2014-01-07     Revised Date:  2014-05-09    
Medline Journal Info:
Nlm Unique ID:  9304532     Medline TA:  Stem Cells     Country:  United States    
Other Details:
Languages:  eng     Pagination:  607-11     Citation Subset:  IM    
Copyright Information:
Copyright © 2012 AlphaMed Press.
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MeSH Terms
Descriptor/Qualifier:
Aging / pathology*
Animals
Cell Aging / physiology
Cell Differentiation / physiology
Disease Models, Animal
Mesenchymal Stem Cell Transplantation / methods*
Mesenchymal Stromal Cells / cytology*
Mice
Mice, Transgenic
Osteoporosis / pathology*
Survival Analysis
Telomere / pathology
Grant Support
ID/Acronym/Agency:
P30 AR050950/AR/NIAMS NIH HHS; R01 AG021521/AG/NIA NIH HHS; R01 AG028873/AG/NIA NIH HHS; R01AG028873/AG/NIA NIH HHS
Comments/Corrections

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