| Long-term follow-up of hypochondriasis after selective serotonin reuptake inhibitor treatment. | |
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MedLine Citation:
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PMID: 21508861 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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BACKGROUND: : There is paucity of knowledge on the long-term outcome of hypochondriasis, with even less knowledge about the effect of treatment with a selective serotonin reuptake inhibitor (SSRI). METHODS: : This prospective follow-up study included 58 patients with Diagnostic and Statistical Manual of Mental Disorders, Fourth Edition (DSM-IV) hypochondriasis who had participated in a trial of SSRI treatment 4 to 16 years earlier (mean ± SD = 8.6 ± 4.5 years). RESULTS: : Information was obtained on 79.3% (n = 46) of the original group. At follow-up, 40% of the patients continued to meet full DSM-IV criteria for hypochondriasis. Persistence of hypochondriasis was individually predicted by longer duration of prior hypochondriasis (P = 0.003), history of childhood physical punishment (P = 0.01), and less usage of SSRIs during the interval period (P = 0.02). Remission status was not significantly predicted by demographic characteristics, baseline hypochondriasis severity, or psychiatric comorbidity. CONCLUSIONS: : A substantial proportion of patients with hypochondriasis who receive treatment with SSRIs achieve remission over the long term. Interim SSRI use may be a factor contributing to better prognosis. |
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Authors:
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Pernilla J Schweitzer; Uzma Zafar; Martina Pavlicova; Brian A Fallon |
Publication Detail:
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Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Journal of clinical psychopharmacology Volume: 31 ISSN: 1533-712X ISO Abbreviation: J Clin Psychopharmacol Publication Date: 2011 Jun |
Date Detail:
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Created Date: 2011-05-02 Completed Date: 2011-08-29 Revised Date: 2012-06-20 |
Medline Journal Info:
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Nlm Unique ID: 8109496 Medline TA: J Clin Psychopharmacol Country: United States |
Other Details:
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Languages: eng Pagination: 365-8 Citation Subset: IM |
Affiliation:
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College of Physicians and Surgeons, and Department of Psychiatry, Columbia University, New York, NY, USA. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adolescent Adult Aged Child Abuse / statistics & numerical data* Clinical Trials as Topic Diagnostic and Statistical Manual of Mental Disorders Female Fluoxetine / therapeutic use* Fluvoxamine / therapeutic use* Follow-Up Studies Humans Hypochondriasis / diagnosis, drug therapy* Male Middle Aged Personality Disorders / complications, drug therapy Remission Induction Serotonin Uptake Inhibitors / therapeutic use* Severity of Illness Index |
| Grant Support | |
ID/Acronym/Agency:
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R29 MH049409/MH/NIMH NIH HHS; R29 MH49409/MH/NIMH NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/Serotonin Uptake Inhibitors; 54739-18-3/Fluvoxamine; 54910-89-3/Fluoxetine |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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