Document Detail


Long-term follow-up of hypochondriasis after selective serotonin reuptake inhibitor treatment.
MedLine Citation:
PMID:  21508861     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
BACKGROUND: : There is paucity of knowledge on the long-term outcome of hypochondriasis, with even less knowledge about the effect of treatment with a selective serotonin reuptake inhibitor (SSRI).
METHODS: : This prospective follow-up study included 58 patients with Diagnostic and Statistical Manual of Mental Disorders, Fourth Edition (DSM-IV) hypochondriasis who had participated in a trial of SSRI treatment 4 to 16 years earlier (mean ± SD = 8.6 ± 4.5 years).
RESULTS: : Information was obtained on 79.3% (n = 46) of the original group. At follow-up, 40% of the patients continued to meet full DSM-IV criteria for hypochondriasis. Persistence of hypochondriasis was individually predicted by longer duration of prior hypochondriasis (P = 0.003), history of childhood physical punishment (P = 0.01), and less usage of SSRIs during the interval period (P = 0.02). Remission status was not significantly predicted by demographic characteristics, baseline hypochondriasis severity, or psychiatric comorbidity.
CONCLUSIONS: : A substantial proportion of patients with hypochondriasis who receive treatment with SSRIs achieve remission over the long term. Interim SSRI use may be a factor contributing to better prognosis.
Authors:
Pernilla J Schweitzer; Uzma Zafar; Martina Pavlicova; Brian A Fallon
Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Journal of clinical psychopharmacology     Volume:  31     ISSN:  1533-712X     ISO Abbreviation:  J Clin Psychopharmacol     Publication Date:  2011 Jun 
Date Detail:
Created Date:  2011-05-02     Completed Date:  2011-08-29     Revised Date:  2012-06-20    
Medline Journal Info:
Nlm Unique ID:  8109496     Medline TA:  J Clin Psychopharmacol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  365-8     Citation Subset:  IM    
Affiliation:
College of Physicians and Surgeons, and Department of Psychiatry, Columbia University, New York, NY, USA.
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MeSH Terms
Descriptor/Qualifier:
Adolescent
Adult
Aged
Child Abuse / statistics & numerical data*
Clinical Trials as Topic
Diagnostic and Statistical Manual of Mental Disorders
Female
Fluoxetine / therapeutic use*
Fluvoxamine / therapeutic use*
Follow-Up Studies
Humans
Hypochondriasis / diagnosis,  drug therapy*
Male
Middle Aged
Personality Disorders / complications,  drug therapy
Remission Induction
Serotonin Uptake Inhibitors / therapeutic use*
Severity of Illness Index
Grant Support
ID/Acronym/Agency:
R29 MH049409/MH/NIMH NIH HHS; R29 MH49409/MH/NIMH NIH HHS
Chemical
Reg. No./Substance:
0/Serotonin Uptake Inhibitors; 54739-18-3/Fluvoxamine; 54910-89-3/Fluoxetine

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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