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Long Term Follow-Up of Early Mycosis Fungoides Patients treated with Narrowband Ultraviolet B Phototherapy.
MedLine Citation:
PMID:  23030414     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
Abstract Background: Narrowband ultraviolet B (UVB) provides complete response (CR) in 54 to 91% of early mycosis fungoides (MF) patients. Data concerning relapse rate and relapse-free interval after discontinuation of therapy need clarification. The purpose of this study was to evaluate the relapse rate and the relapse-free intervals of early MF patients after achieving complete response with narrowband UVB phototherapy. Methods: Retrospective evaluation of data, which belong to early MF patients treated with narrowband UVB phototherapy between May 2000 and July 2010, and followed-up until May 2012 in a single institution, for the occurrence of relapse and the time to relapse. Results: Of 31 patients, who were followed-up for a mean of 56.5±30.2 months, (median 55 months, range 20-120 months). Relapse was observed in 11 (35.5%) of these patients, within a mean of 28.8 ± 18.2 months (median, 33 months, range, 4-59 months), whereas 20 (64.5%) patients stayed relapse-free for a mean of 54.2 ± 28.8 months (median, 55.5 months, range, 20 -119 months). Patients received maintenance phototherapy with a median duration of 12 months (range 1-30 months) after achieving complete response. Conclusion: Results indicate that narrowband UVB phototherapy may induce low relapse rates and long relapse-free intervals for early MF.
Authors:
Gonca Elcin; Nilay Duman; Sevilay Karahan; Sibel Ersoy-Evans; Gul Erkin; Aysen Karaduman; Asli Hapa; Nilgün Atakan; Tulin Akan; Sedef Sahin
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2012-10-3
Journal Detail:
Title:  The Journal of dermatological treatment     Volume:  -     ISSN:  1471-1753     ISO Abbreviation:  J Dermatolog Treat     Publication Date:  2012 Oct 
Date Detail:
Created Date:  2012-10-3     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8918133     Medline TA:  J Dermatolog Treat     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Affiliation:
Hacettepe University Faculty of Medicine Department of Biostatistics , Ankara , Turkey.
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