| Long-Term Exposure to Ambient Fine Particulate Pollution Induces Insulin Resistance and Mitochondrial Alteration in Adipose Tissue. | |
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MedLine Citation:
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PMID: 21873646 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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Objectives: We have previously shown that chronic exposure to ambient fine particulate matter (less than 2.5 μm in aerodynamic diameter, PM(2.5)) pollution in conjunction with high-fat diet induces insulin resistance through alterations in inflammatory pathways. In this study we evaluated the effects of PM(2.5) exposure over a substantive duration of a rodent's lifespan and focused on the impact of long-term exposure on adipose structure and function.Methods and Results: C57BL/6 mice were exposed to PM(2.5) or filtered air (FA) (6 hours/day, 5 days/week) for duration of 10 months in Columbus, OH. At the end of the exposure, PM(2.5)-exposed mice demonstrated insulin resistance (IR) and a decrease in glucose tolerance compared with the FA-exposed group. Although there were no significant differences in circulating cytokines between PM(2.5)- and FA-exposed groups, circulating adiponectin and leptin were significantly decreased in PM(2.5)-exposed group. PM(2.5) exposure also led to inflammatory response and oxidative stress as evidenced by increase of Nrf2-regulated antioxidant genes. Additionally, PM(2.5) exposure decreased mitochondrial count in visceral adipose and mitochondrial size in interscapular adipose depots, which were associated with reduction of uncoupling protein 1 (UCP1) expression and down-regulation of brown adipocyte-specific gene profiles.Conclusions: Long-term ambient PM(2.5) exposure induces impaired glucose tolerance, IR, inflammation, and mitochondrial alteration, and thus it is a risk factor for the development of type 2 diabetes. |
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Authors:
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Xiaohua Xu; Cuiqing Liu; Zhaobin Xu; Kevin Tzan; Mianhua Zhong; Aixia Wang; Morton Lippmann; Lung-Chi Chen; Sanjay Rajagopalan; Qinghua Sun |
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Publication Detail:
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Type: JOURNAL ARTICLE Date: 2011-8-27 |
Journal Detail:
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Title: Toxicological sciences : an official journal of the Society of Toxicology Volume: - ISSN: 1096-0929 ISO Abbreviation: - Publication Date: 2011 Aug |
Date Detail:
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Created Date: 2011-8-29 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9805461 Medline TA: Toxicol Sci Country: - |
Other Details:
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Languages: ENG Pagination: - Citation Subset: - |
Affiliation:
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Division of Environmental Health Sciences, College of Public Health. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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