Document Detail

Long-term exercise-training improves QT dispersion in the metabolic syndrome.
MedLine Citation:
PMID:  20145350     Owner:  NLM     Status:  MEDLINE    
Increased QT dispersion (QTd) is a marker of myocardial electrical instability and predicts ventricular arrhythmias and sudden cardiac death. Exercise training (ET) has been shown to reduce both QTd and cardiovascular mortality in various populations. Patients with metabolic syndrome (MS) have been shown to have increased QTd. The effect of ET on QTd in MS patients however is unknown. We sought to assess the effect of a long-term (> or = 6 months) ET program on QTd parameters in MS patients with and without coronary heart disease (CHD). Fifteen CHD and 31 non-CHD patients with MS (mean age, 64 +/- 7 and 57 +/- 9 years, respectively) were identified at entry into identical ET programs. MS was defined using modified National Cholesterol Education Program criteria. A control group consisted of 8 MS patients with CHD (mean age, 65 +/- 6 years). Ventricular repolarization (QT dispersion = QTd, standard deviation of QT = SDQT, relative dispersion of QT = RDQT, QT corrected dispersion = QTcd), metabolic and exercise parameters were measured before and after ET. Program duration was over 9 months (312 +/- 100 versus 284 +/- 101 days in CHD and non-CHD cohorts, P = NS). QTd decreased in both ET groups (QTd pre versus post = 66 versus 56 ms in CHD group, P < 0.01; 58 versus 51 ms in non-CHD group, P < or = 0.01). Other ventricular repolarization parameters also improved significantly in both MS groups following ET, but remained unchanged in the control group. A long-term ET program improves QTd in patients with MS with and without CHD.
Thibaut Guiraud; Mathieu Gayda; Daniel Curnier; Martin Juneau; Mario Talajic; Annik Fortier; Anil Nigam
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  International heart journal     Volume:  51     ISSN:  1349-2365     ISO Abbreviation:  Int Heart J     Publication Date:  2010 Jan 
Date Detail:
Created Date:  2010-02-10     Completed Date:  2010-03-23     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101244240     Medline TA:  Int Heart J     Country:  Japan    
Other Details:
Languages:  eng     Pagination:  41-6     Citation Subset:  IM    
Cardiovascular Prevention Centre, Montreal Heart Institute, Canada.
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MeSH Terms
Coronary Disease / complications,  physiopathology*,  therapy
Exercise Test
Exercise Therapy*
Heart Conduction System / physiopathology*
Metabolic Syndrome X / complications,  physiopathology*,  therapy
Middle Aged
Retrospective Studies

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