Document Detail

Long-term efficacy of pravastatin therapy in diabetic patients undergoing complete coronary revascularization.
MedLine Citation:
PMID:  20154448     Owner:  NLM     Status:  MEDLINE    
AIM: The long-term effect of statin therapy in diabetic patients after coronary revascularization is not well established. Accordingly, we sought to determine if whether statin therapy initiated at the time of complete revascularization including percutaneous coronary intervention (PCI) and/or bypass surgery reduces total and cardiac mortality among diabetic patients. METHODS: We collected data from 1,138 consecutive patients who underwent complete revascularization (PCI and/or bypass surgery). We then compared all-cause and cardiac mortality rates in 499 patients with diabetes mellitus of whom 149 (29.9%) were treated with statin at the time of revascularization. To adjust the variables that would have been related to the decision regarding statin administration, a propensity score was computed and multivariate Cox regression was carried out. RESULTS: During follow-up (8.8+/-2.6 years), 103 patients died (including 43 who died of cardiac causes). The Multivariate analysis showed statin therapy to be significantly associated with reduced cardiac mortality (HR 0.39, 0.16-0.95; p=0.039), but not with all-cause mortality. CONCLUSION: Statin therapy was associated with a significantly reduced risk of cardiac mortality in patients with diabetes mellitus and coronary artery disease after complete revascularization.
Kouichiro Aihara; Katsumi Miyauchi; Takatoshi Kasai; Naozumi Kubota; Kan Kajimoto; Hiroshi Tamura; Takahiko Kojima; Ken Yokoyama; Takeshi Kurata; Atsushi Amano; Hiroyuki Daida
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Publication Detail:
Type:  Journal Article     Date:  2010-02-13
Journal Detail:
Title:  Journal of atherosclerosis and thrombosis     Volume:  17     ISSN:  1880-3873     ISO Abbreviation:  J. Atheroscler. Thromb.     Publication Date:  2010 Apr 
Date Detail:
Created Date:  2010-05-10     Completed Date:  2010-08-24     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9506298     Medline TA:  J Atheroscler Thromb     Country:  Japan    
Other Details:
Languages:  eng     Pagination:  350-5     Citation Subset:  IM    
Department of Cardiovascular Medicine, Juntendo University, School of Medicine, Tokyo, Japan.
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MeSH Terms
Coronary Artery Disease / drug therapy*,  etiology*,  surgery
Diabetes Complications / drug therapy*,  pathology
Diabetes Mellitus / drug therapy*,  pathology
Hydroxymethylglutaryl-CoA Reductase Inhibitors / therapeutic use*
Middle Aged
Myocardial Revascularization*
Pravastatin / therapeutic use*
Risk Factors
Survival Rate
Treatment Outcome
Reg. No./Substance:
0/Hydroxymethylglutaryl-CoA Reductase Inhibitors; 81093-37-0/Pravastatin

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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