Long-Term Effects of Transcatheter Closure of Atrial Septal Defect on Cardiac Remodeling and Exercise Capacity in Patients Older than 40 Years with a Reduction in Cardiopulmonary Function.

Long-Term Effects of Transcatheter Closure of Atrial Septal Defect on Cardiac Remodeling and Exercise Capacity in Patients Older than 40 Years with a Reduction in Cardiopulmonary Function.

MedLine Citation:	PMID: 23163398 Owner: NLM Status: Publisher
Abstract/OtherAbstract:	Background: Although it has been demonstrated that cardiac remodeling and exercise capacity improve after transcatheter closure of atrial septal defect (ASD), little is known about long-term benefits in middle-aged and elderly patients with a reduction in cardiopulmonary function. Objectives: To evaluate long-term extent and time course of improvements in cardiac remodeling and exercise capacity in those patients. Methods: Twenty ASD patients ≥ 40 years of age with a reduction in cardiopulmonary function (predicted peak oxygen uptake [VO(2) ] < 65%) were enrolled. Transthoracic echocardiography and cardiopulmonary exercise testing were performed at baseline and at 1 month, 3 months, 6 months, and >12 months after the procedure. Results: At 1 month after the procedure, significant decreases in right ventricular (RV) end-diastolic diameter (38.2 ± 4.4 to 31.9 ± 4.4 mm; P < 0.001) and RV/left ventricular end-diastolic diameter ratio (0.95 ± 0.17 to 0.71 ± 0.13; P < 0.001) occurred, and they were maintained during the follow-up period. Normal RV size was achieved in 11 of 18 patients with RV enlargement. Predicted peak VO(2) did not change at 1 month and 3 months, but it improved significantly after 6 months (53.6 ± 6.5 to 62.1 ± 12.6%; P < 0.01). Sixteen of the 20 patients showed improved predicted peak VO(2) . Conclusions: Cardiac remodeling and exercise capacity could be improved over the long-term period after transcatheter closure of ASD in middle-aged and elderly patients with a reduction in cardiopulmonary function. There were differences in the time course of improvement between cardiac remodeling and exercise capacity in those patients. (J Interven Cardiol 2012;**:1-5).

Authors:	Yoichi Takaya; Manabu Taniguchi; Teiji Akagi; Saori Nobusada; Kengo Kusano; Hiroshi Ito; Shunji Sano
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Publication Detail:	Type: JOURNAL ARTICLE Date: 2012-11-19
Journal Detail:	Title: Journal of interventional cardiology Volume: - ISSN: 1540-8183 ISO Abbreviation: J Interv Cardiol Publication Date: 2012 Nov
Date Detail:	Created Date: 2012-11-20 Completed Date: - Revised Date: -
Medline Journal Info:	Nlm Unique ID: 8907826 Medline TA: J Interv Cardiol Country: -
Other Details:	Languages: ENG Pagination: - Citation Subset: -
Copyright Information:	©2012, Wiley Periodicals, Inc.
Affiliation:	Department of Cardiovascular Medicine, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama, Japan Division of Cardiac Intensive Care Unit, Okayama University Hospital, Okayama, Japan Division of Cardiovascular Medicine, Fukuyama Cardiovascular Hospital, Fukuyama, Japan Division of Central Clinical Laboratory, Okayama University Hospital, Okayama, Japan Department of Cardiovascular Surgery, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama, Japan.
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