| Long-term effects of pioglitazone on carotid atherosclerosis in Japanese patients with type 2 diabetes without a recent history of macrovascular morbidity. | |
| | |
MedLine Citation:
|
PMID: 20686324 Owner: NLM Status: In-Process |
Abstract/OtherAbstract:
|
AIM: No previous studies have evaluated the long-term anti-atherosclerotic effects of pioglitazone in Asian patients with type 2 diabetes. Therefore, the present study investigated the protective effects of pioglitazone on the progression of carotid intima-media thickness (IMT), an established surrogate marker of cardiovascular events in Japanese type 2 diabetic patients without a recent history of cardiovascular morbidity. METHODS: This 2.5-4-year, randomized, open-label, blinded endpoint study was conducted in 6 centers across Japan. Patients received pioglitazone with or without other oral glucose-lowering drugs (excluding another thiazolidinedione) (n=89) or oral glucose-lowering drugs, excluding thiazolidinediones (n=97). Treatment was adjusted to achieve HbA(1c) <6.5%. The primary endpoints of the study were the absolute changes from the baseline to final visit in max- and mean-IMT in the average of bilateral common carotid arteries. RESULTS: Pioglitazone induced carotid IMT regression compared to baseline measurements (from 1.060 ± 0.2368 to 0.992 ± 0.1921 mm; p=0.0042 in max-IMT and from 0.839 ± 0.1873 to 0.780 ± 0.1571 mm; p=0.0019 in mean-IMT). Although the between-group difference did not reach statistical significance, the regression of carotid IMT values was greater in the pioglitazone-treatment group than in the non-pioglitazone group, (max-IMT: -0.069 ± 0.2199 mm vs -0.031 ± 0.2327 mm, respectively; p=NS, mean-IMT: -0.058 ± 0.1718 mm vs -0.043 ± 0.1644 mm, respectively; p=NS). CONCLUSIONS: Pioglitazone induced and maintained the long-term regression of carotid IMT in Japanese type 2 diabetic patients. This suggests that pioglitazone may inhibit the progression of atherosclerosis in this patient group. Further studies are required to verify these findings. |
| | |
Authors:
|
Yoshimitsu Yamasaki; Naoto Katakami; Shigetaka Furukado; Kazuo Kitagawa; Kazuyuki Nagatsuka; Atsunori Kashiwagi; Hiroyuki Daida; Ryuzo Kawamori; Kohei Kaku |
Related Documents
:
|
11921434 - Differentiating members of the thiazolidinedione class: a focus on efficacy. 18038714 - Effect of metformin and rosiglitazone in a prepubertal boy with alström syndrome. 9597374 - Evidence for dissociation of insulin- and weight-reducing effects of metformin in non-d... 11436194 - Metformin reduces weight, centripetal obesity, insulin, leptin, and low-density lipopro... 18629364 - Implications of the obesity epidemic for lipid-lowering therapy: non-hdl cholesterol sh... 3547014 - Metabolic factors in the insulin resistance in human obesity. |
Publication Detail:
|
Type: Journal Article; Research Support, Non-U.S. Gov't Date: 2010-07-31 |
Journal Detail:
|
Title: Journal of atherosclerosis and thrombosis Volume: 17 ISSN: 1880-3873 ISO Abbreviation: J. Atheroscler. Thromb. Publication Date: 2010 Nov |
Date Detail:
|
Created Date: 2010-12-03 Completed Date: - Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 9506298 Medline TA: J Atheroscler Thromb Country: Japan |
Other Details:
|
Languages: eng Pagination: 1132-40 Citation Subset: IM |
Affiliation:
|
Department of Internal Medicine and Therapeutics, Osaka University Graduate School of Medicine, Osaka, Japan. yamasaki@medone.med.osaka-u.ac.jp |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
|
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Susac syndrome.
Next Document: Beneficial effects of mild stress (hormetic effects): dietary restriction and health.