| Long-term effects of growth hormone therapy on patients with Prader-Willi syndrome. | |
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MedLine Citation:
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PMID: 20545932 Owner: NLM Status: In-Process |
Abstract/OtherAbstract:
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AIM: To assess the effects of recombinant human growth hormone (rhGH) treatment in children with Prader-Willi syndrome. DESIGN: A 1-year study and an observational follow-up visit 10 years later. METHODS: In 20 patients with Prader-Willi syndrome (PWS): clinical assessment, laboratory tests, body composition analysis by dual energy X-ray absorptiometry, sleep polygraphy, health-related quality of life assessed by 16D. RESULTS: Only two patients had normal growth hormone secretion at baseline. All patients were significantly shorter than their expected heights, but experienced catch-up growth during growth hormone treatment. At follow-up, 13 patients had reached adult heights and were markedly taller than historical controls. The cumulative dose of rhGH over 10 years correlated inversely with the total body fat percentage (p = 0.033). However, patients remained severely obese at 10 years. Sleep polygraphy was abnormal in more than half of the patients. Health-related quality of life of the patients remained substantially below that of normal population. CONCLUSION: Growth hormone markedly improved adult height in subjects with PWS when compared to historical data. The cumulative dose of growth hormone correlated with reduction in body fat; nevertheless, patients remained severely obese. |
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Authors:
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Ilkka Sipilä; Harri Sintonen; Heikki Hietanen; Marjo Apajasalo; Soili Alanne; Anna-Mari Viita; Eeva Leinonen |
Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't Date: 2010-07-05 |
Journal Detail:
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Title: Acta paediatrica (Oslo, Norway : 1992) Volume: 99 ISSN: 1651-2227 ISO Abbreviation: Acta Paediatr. Publication Date: 2010 Nov |
Date Detail:
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Created Date: 2010-11-02 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9205968 Medline TA: Acta Paediatr Country: Norway |
Other Details:
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Languages: eng Pagination: 1712-8 Citation Subset: IM |
Copyright Information:
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© 2010 Eli Lilly and Company/Journal Compilation © 2010 Foundation Acta Paediatrica. |
Affiliation:
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Hospital for Children and Adolescents, Paediatrics, University of Helsinki, Helsinki, Finland. ilkka.sipila@fimnet.fi |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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