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Long-Term Effectiveness of Non-Drug Recommendations to Treat Hypertension in a Clinical Setting.
MedLine Citation:
PMID:  22810842     Owner:  NLM     Status:  Publisher    
BackgroundNonpharmacological interventions have been efficacious to control blood pressure (BP) in clinical trials, but their long-term effectiveness in clinical practice was still not documented.MethodsThis is a prospective cohort study of 825 patients who received repeated nonpharmacological recommendations to treat hypertension. The outcomes were BP change and rate of BP control by pattern of adherence (informed by the patients) to the recommendations to follow low-salt and low-calorie diets and to do physical activities.ResultsPatients were followed for 23.1 ± 8.4 months. Between group deltas of BP change in patients with and without adherence to the low-salt diet, adjusted for baseline BP, body mass index (BMI), age, and number of drugs in use, were 5.1 (95% confidence interval: 1.7-8.6) mm Hg for systolic (P = 0.003) and 2.1 (0.2-3.9) mmHg for diastolic BP (P = 0.02). For adherence to low-calorie diet, the deltas were 6.6 (2.9-10.2) mm Hg (P < 0.001) and 2.0 (0.1-3.9) mm Hg (P = 0.045). Adherence to physical activities was not associated with a BP-lowering effect. Relative risks for a fall of 10 mm Hg in systolic or 5 mm Hg in diastolic BP, with adjustment for confounding, were 0.69 (95% confidence interval: 0.55-0.87) for adherence to the low-salt diet, 0.83 (0.66-1.05) for low-calorie diet, and 0.99 (0.79-1.24) for exercise.ConclusionsAdherence to low-salt and low-calorie diets is associated with clinically relevant long-term BP reduction and better hypertension control in a clinical setting.American Journal of Hypertension 2012; doi:10.1038/ajh.2012.103.
Glaube Riegel; Leila B Moreira; Sandra C Fuchs; Miguel Gus; Gerson Nunes; Vicente Correa; Mário Wiehe; Carla C Gonçalves; Fernando S Fernandes; Flávio D Fuchs
Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2012-7-19
Journal Detail:
Title:  American journal of hypertension     Volume:  -     ISSN:  1941-7225     ISO Abbreviation:  -     Publication Date:  2012 Jul 
Date Detail:
Created Date:  2012-7-19     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8803676     Medline TA:  Am J Hypertens     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Graduate Studies Program in Cardiology, Hospital de Clínicas de Porto Alegre, Porto Alegre, Brazil.
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