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Long-Term Decline of Central Cone Function in Retinitis Pigmentosa Evaluated by Focal Electroretinogram.
MedLine Citation:
PMID:  23111612     Owner:  NLM     Status:  Publisher    
PURPOSE: To evaluate long term changes of central cone-mediated function in retinitis pigmentosa (RP) patients by recording focal electroretinograms (fERG). Methods: A cohort of 43 RP patients was followed from 4 to 16 years (average follow up = 9.3 year, average examination/patient =10) by recording the fERG response to a flickering uniform red field overlaying the central 18 deg of visual field. Statistical censoring led to a reduced dataset of 32 patients (autosomal dominant, 9; recessive, 5; sporadic, 5; x-linked, 1, Usher II, 12), from which long-term decay rates were estimated by global fitting of individual fERG amplitude time-curves. Results: Long term follow up of central cone fERG amplitude showed two main features: short term variability and long term decline. fERG short term variability range was 0.14-0.2 log unit. Mean yearly decay rate of central fERG was 5,6% (95% confidence interval: 4% - 7%). Yearly decline depended on inheritance pattern, being significantly greater in autosomal recessive and sporadic compared to autosomal dominant RP. The degree of central cone fERG decline was unrelated to the size of the residual visual field. Conclusions: The decline of central cone function is significantly slower than global cone function decline in RP. Central cone fERG loss is independent of residual visual field.
Benedetto Falsini; Lucia Galli-Resta; Antonello Fadda; Lucia Ziccardi; Marco Piccardi; Giancarlo Iarossi; Giovanni Resta
Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2012-10-30
Journal Detail:
Title:  Investigative ophthalmology & visual science     Volume:  -     ISSN:  1552-5783     ISO Abbreviation:  Invest. Ophthalmol. Vis. Sci.     Publication Date:  2012 Oct 
Date Detail:
Created Date:  2012-10-31     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  7703701     Medline TA:  Invest Ophthalmol Vis Sci     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Istituto di Oftalmologia, Universita Cattolica del S. Cuore, Lgo F. Vito 1, Rome, 00168, Italy.
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