Document Detail


Long-term clinical outcome after endovascular treatment in patients with intermittent claudication due to iliofemoral artery disease.
MedLine Citation:
PMID:  20574137     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
BACKGROUND: The natural history of patients with intermittent claudication (IC) has been reported, but little is known about that of claudicant patients after endovascular therapy (EVT).
METHODS AND RESULTS: A total of 271 consecutive patients (mean age, 68+/-6 years, 82% men) with IC were treated with EVT for a de novo iliofemoral lesion. Primary patency was defined as treated vessel without re-stenosis and repeat revascularization. Major adverse cardiovascular event (MACE) included death, myocardial infarction and stroke. Median follow-up interval was 11.7+/-2.9 years. During the follow-up period, 132 patients died (cardiovascular death; 66%). Major amputation was performed in 4 patients. Primary patency rate was 82%, 79%, and 78% at 5, 10 and 15 years, respectively. Freedom from all-cause death (MACE) was 73% (69%), 58% (49%), and 43% (34%) at 5, 10 and 15 years. On multivariate Cox regression, Trans-Atlantic Inter-society Consensus grade C/D, and involvement of femoropopliteal lesion were independent predictors of primary patency. Independent predictors for overall survival were age, left ventricular dysfunction (ejection fraction <40%), coronary artery disease, diabetes, chronic kidney disease and below-the-knee disease.
CONCLUSIONS: Regardless of good clinical patency of treated vessel in patients with IC, survival was poor. Independent predictors were different between long-term patency and late mortality.
Authors:
Yoshimitsu Soga; Hiroyoshi Yokoi; Tomoko Urakawa; Atsushi Tosaka; Masashi Iwabuchi; Masakiyo Nobuyoshi
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Publication Detail:
Type:  Journal Article     Date:  2010-06-22
Journal Detail:
Title:  Circulation journal : official journal of the Japanese Circulation Society     Volume:  74     ISSN:  1347-4820     ISO Abbreviation:  Circ. J.     Publication Date:  2010 Aug 
Date Detail:
Created Date:  2010-07-30     Completed Date:  2010-12-06     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101137683     Medline TA:  Circ J     Country:  Japan    
Other Details:
Languages:  eng     Pagination:  1689-95     Citation Subset:  IM    
Affiliation:
Department of Cardiology, Kokura Memorial Hospital, Kitakyushu 802-8555, Japan. sogacchy@yahoo.co.jp
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MeSH Terms
Descriptor/Qualifier:
Aged
Coronary Artery Disease
Endovascular Procedures*
Femoral Artery / pathology*
Humans
Intermittent Claudication / etiology,  mortality,  therapy*
Middle Aged
Stroke Volume
Survival Rate
Treatment Outcome
Vascular Diseases / complications*
Vascular Patency

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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