Document Detail

Long-term clinical implication of the occurrence of dissociated pulmonary vein activities after circumferential left atrial ablation in patients with paroxysmal atrial fibrillation.
MedLine Citation:
PMID:  21071875     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: The incidence and clinical implication of dissociated pulmonary vein (PV) electrical activities after circumferential antrum PV ablation for paroxysmal atrial fibrillation (AF) remains unclear.
METHODS AND RESULTS: A total of 196 patients with symptomatic paroxysmal AF who underwent circumferential antrum PV ablation were prospectively studied. Dissociated PV electrical activities were observed in 101 patients (Group 1), but absent in the remaining 95 patients (Group 2). There were no significant differences in the baseline clinical characteristics between them, except that Group 2 had a higher prevalence of hypertension (30 vs. 44%, P = 0.04). After 21.8 ± 7.9 months of follow-up, 148 had no recurrence of AF after the initial procedure. AF recurrence rate was significantly higher in Group 2 than in Group 1 (P = 0.023). Relapse of PV conduction was the major cause of AF recurrence in both groups (16/16 vs. 19/23, P = 0.08), and the overall procedural success rate after the redo ablation procedure was similar in the 2 groups (90 vs. 86%, P = 0.44). However, the total number of patients with non-PV foci was significantly higher in Group 2 than in Group 1 (12/95 vs. 2/101, P < 0.01).
CONCLUSIONS: Dissociated PV electrical activities might identify a subgroup of patients with relatively higher initial procedural success with circumferential PV antrum ablation.
Hongwu Chen; Bing Yang; Weizhu Ju; Fengxiang Zhang; Xiaofeng Hou; Chun Chen; Lishang Zhai; Jing Wang; Kejiang Cao; Minglong Chen; Hung-Fat Tse
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2010-11-07
Journal Detail:
Title:  Circulation journal : official journal of the Japanese Circulation Society     Volume:  75     ISSN:  1347-4820     ISO Abbreviation:  Circ. J.     Publication Date:  2011  
Date Detail:
Created Date:  2010-12-28     Completed Date:  2011-02-25     Revised Date:  2012-01-09    
Medline Journal Info:
Nlm Unique ID:  101137683     Medline TA:  Circ J     Country:  Japan    
Other Details:
Languages:  eng     Pagination:  73-9     Citation Subset:  IM    
Division of Cardiology, The First Affiliated Hospital of Nanjing Medical University, Nanjing, Jiangsu, China.
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MeSH Terms
Atrial Fibrillation / physiopathology,  surgery*
Catheter Ablation*
Chi-Square Distribution
Electrophysiologic Techniques, Cardiac
Kaplan-Meier Estimate
Middle Aged
Patient Selection
Prospective Studies
Pulmonary Veins / physiopathology,  surgery*
Risk Assessment
Risk Factors
Time Factors
Treatment Outcome

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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