Document Detail

Long-term clinical and histological analysis of Integra dermal regeneration template.
MedLine Citation:
PMID:  21088647     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: This study looked at clinical and histological outcomes of patients treated with Integra more than 2 years earlier. Although previous studies have investigated the short-term clinical and histological results, there have been no studies to investigate longer-term changes.
METHODS: Fourteen patients (23 sites) were assessed. Patients used a visual analogue scale to score characteristics of their scars. Objective evaluation of the reconstructions was carried out using the Cutometer MPA580. Punch biopsy specimens of the sites were stained and labeled immunohistochemically with S100, CD31, and CD34 antisera.
RESULTS: The highest scoring category by patients was softness (median, +45 percent). The lowest score was sweating, which all patients scored 0. The median Cutometer readings ranged from 39 to 52 percent of the control values. Histological examination showed three patterns of collagen arrangement; parallel arrangement was found in over 60 percent of specimens. Elastic fibers were identified in all specimens; however, all were of abnormal morphology. The majority of specimens showed evidence of nerve fiber regeneration although confined to the mid- or lower reticular dermis. There was no regeneration of skin adnexa.
CONCLUSIONS: This study showed significant improvements in patient-assessed mobility, softness, and appearance. Collagen and elastic fibrin were present in all specimens, nerve fiber regeneration was limited to the mid- or lower reticular dermis, and adnexal structures were absent. The typical wrinkled appearance of mature Integra reconstruction cannot be said to be entirely due to a lack of elastic fibers.
Naiem Moiemen; Jeremy Yarrow; Elaine Hodgson; Jiannis Constantinides; Elizabeth Chipp; H Oakley; Elizabeth Shale; Martin Freeth
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Publication Detail:
Type:  Comparative Study; Journal Article    
Journal Detail:
Title:  Plastic and reconstructive surgery     Volume:  127     ISSN:  1529-4242     ISO Abbreviation:  Plast. Reconstr. Surg.     Publication Date:  2011 Mar 
Date Detail:
Created Date:  2011-04-07     Completed Date:  2011-04-26     Revised Date:  2014-10-13    
Medline Journal Info:
Nlm Unique ID:  1306050     Medline TA:  Plast Reconstr Surg     Country:  United States    
Other Details:
Languages:  eng     Pagination:  1149-54     Citation Subset:  AIM; IM    
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MeSH Terms
Chondroitin Sulfates*
Cicatrix / pathology,  surgery*
Follow-Up Studies
Middle Aged
Reconstructive Surgical Procedures / methods*
Skin Aging
Skin Transplantation / methods*
Skin, Artificial
Time Factors
Treatment Outcome
Wound Healing / physiology*
Young Adult
Reg. No./Substance:
0/integra artificial skin; 9007-28-7/Chondroitin Sulfates; 9007-34-5/Collagen

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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