| Long-term clinical course of patients with isolated myocardial bridge. | |
| | |
MedLine Citation:
|
PMID: 20103971 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
BACKGROUND: Myocardial bridge (MB) is regarded as a common benign lesion on coronary angiography (CAG). It is known to be harmless but may cause several cardiac events and recurrent hospitalization, so in the present study the long-term clinical course of patients with isolated MB and predictors of readmission were investigated. METHODS AND RESULTS: Total 684 patients (343 males, 60.5+/-11.2 years) with persistent chest pain without critical stenosis on CAG were enrolled. The patients were divided into 2 groups according to the presence of MB. Clinical follow-up was performed with respect to readmission after baseline CAG. At a mean follow-up of 37 months, 92 patients (13.3%) were re-admitted because of 79 recurrent chest pain refractory to medication (11.5%), 8 myocardial infarctions (1.2%), 1 life-threatening arrhythmia (0.1%) and 4 deaths (0.6%). There was a significant higher incidence of readmission in the MB group (P=0.038). In multivariate analysis, long MB (hazard ratio (HR) 2.780; 95% confidence interval (CI) 1.070-7.218, P=0.036) and spontaneous vasospasm in CAG (HR 2.335; 95%CI 1.055-5.171, P=0.037) were the predictors of readmission. Moreover, additional use of aspirin or statin decreased the readmission rate. CONCLUSIONS: This study suggests that MB on non-occlusive CAG is not benign and may cause recurrent chest pain, myocardial infarction or life-threatening arrhythmia. Especially, patients with a long MB and vasospasm on CAG need intensive medical therapy, including antiplatelet treatment. |
| | |
Authors:
|
Sung-Soo Kim; Myung Ho Jeong; Hyun Kuk Kim; Min Chul Kim; Kyung Hun Cho; Min Goo Lee; Jum Suk Ko; Keun Ho Park; Doo Sun Sim; Nam Sik Yoon; Hyun Ju Yoon; Hyung Wook Park; Ju Han Kim; Young Joon Hong; Young Keun Ahn; Jeong Gwan Cho; Jong Chun Park; Jung Chaee Kang |
Publication Detail:
|
Type: Journal Article; Research Support, Non-U.S. Gov't Date: 2010-01-26 |
Journal Detail:
|
Title: Circulation journal : official journal of the Japanese Circulation Society Volume: 74 ISSN: 1347-4820 ISO Abbreviation: Circ. J. Publication Date: 2010 Mar |
Date Detail:
|
Created Date: 2010-02-26 Completed Date: 2010-05-24 Revised Date: 2011-02-18 |
Medline Journal Info:
|
Nlm Unique ID: 101137683 Medline TA: Circ J Country: Japan |
Other Details:
|
Languages: eng Pagination: 538-43 Citation Subset: IM |
Affiliation:
|
Department of Internal Medicine, Chonnam National University Hospital, Gwangju, Republic of Korea. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Aged Angina Pectoris / epidemiology Aspirin / therapeutic use Coronary Angiography Coronary Vasospasm / epidemiology* Female Follow-Up Studies Hospitalization / statistics & numerical data Humans Male Middle Aged Multivariate Analysis Myocardial Bridging / drug therapy, epidemiology*, radiography Myocardial Infarction / epidemiology* Patient Discharge Patient Readmission / statistics & numerical data* Platelet Aggregation Inhibitors / therapeutic use Predictive Value of Tests Proportional Hazards Models Recurrence Retrospective Studies Risk Factors |
| Chemical | |
Reg. No./Substance:
|
0/Platelet Aggregation Inhibitors; 50-78-2/Aspirin |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Two-year clinical outcome after abciximab-coated stent implantation in patients with coronary artery...
Next Document: Metabolic syndrome and carotid artery parameter in Koreans aged 50 years and older.