Document Detail


Long-Term Alteration in Maternal Blood Pressure and Renal Function After Pregnancy in Normal and Growth-Restricted Rats.
MedLine Citation:
PMID:  22585946     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
Intrauterine growth restriction is associated with increased risk of adult cardiorenal diseases. Small birth weight females are more likely to experience complications during their own pregnancy, including pregnancy-induced hypertension, preeclampsia, and gestational diabetes. We determined whether the physiological demand of pregnancy predisposes growth-restricted females to cardiovascular and renal dysfunction later in life. Late gestation bilateral uterine vessel ligation was performed in Wistar-Kyoto rats. At 4 months, restricted and control female offspring were mated with normal males and delivered naturally (ex-pregnant). Regardless of maternal birth weight, at 13 months, ex-pregnant females developed elevated mean arterial pressure (indwelling tail-artery catheter; +6 mm Hg), reduced effective renal blood flow ((14)C-PAH clearance; -23%), and increased renal vascular resistance (+27%) compared with age-matched virgins. Glomerular filtration rate ((3)H-inulin clearance) was not different across groups. This adverse cardiorenal phenotype in ex-pregnant females was associated with elevated systemic (+57%) and altered intrarenal components of the renin-angiotensin system. After pregnancy at 13 months, coronary flow (Langendorff preparation) was halved in restricted females compared with controls, and together with reduced NO excretion, this may increase susceptibility to additional lifestyle challenges. Our results have implications for aging females who have been pregnant, suggesting long-term cardiovascular and renal alterations, with additional consequences for females who were small at birth.
Authors:
Linda A Gallo; Kate M Denton; Karen M Moritz; Marianne Tare; Helena C Parkington; Meagan Davies; Melanie Tran; Andrew J Jefferies; Mary E Wlodek
Related Documents :
23201846 - Does a low glycaemic index (gi) diet cost more during pregnancy?
1477016 - Perinatal outcome of pregnancies complicated by vaginal bleeding.
23209926 - Assessment of the safety and efficacy of a raft-forming alginate reflux suppressant (li...
20863516 - Effects of pre-pregnancy body mass index and gestational weight gain on infant anthropo...
86216 - Allo-anti-c in a patient who had previously made an autoantibody mimicking anti-c.
956146 - Synergistic action of two different types of endo-cellulase components from irpex lacte...
Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2012-5-14
Journal Detail:
Title:  Hypertension     Volume:  -     ISSN:  1524-4563     ISO Abbreviation:  -     Publication Date:  2012 May 
Date Detail:
Created Date:  2012-5-15     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  7906255     Medline TA:  Hypertension     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Affiliation:
Department of Physiology, University of Melbourne, Parkville, Victoria, Australia; Department of Physiology, Monash University, Clayton, Victoria, Australia; School of Biomedical Sciences, University of Queensland, St Lucia, Queensland, Australia.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  Oxidative stress contributes to sex differences in blood pressure in adult growth-restricted offspri...
Next Document:  Cardiorespiratory Fitness Reduces the Risk of Incident Hypertension Associated With a Parental Histo...