| Long-Term (>10 Years) Clinical Outcomes of First-In-Man Biodegradable Poly-l-lactic Acid Coronary Stents: Igaki-Tamai Stents. | |
| | |
MedLine Citation:
|
PMID: 22508795 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
|
BACKGROUND: The purpose of this study was to evaluate the long-term safety of the Igaki-Tamai stent, the first-in-man fully biodegradable coronary stent made of poly-l-lactic acid. METHODS AND RESULTS: Between September 1998 and April 2000, 50 patients with 63 lesions were treated electively with 84 Igaki-Tamai stents. Overall clinical follow-up (>10 years) of major adverse cardiac events (MACE) and rates of scaffold thrombosis were analyzed together with the results of angiography and intravascular ultrasound (IVUS). MACE included all-cause death, nonfatal myocardial infarction (MI) and target lesion revascularization / target vessel revascularization (TLR/TVR). During the overall clinical follow-up period (121±17 months), 2 patients were lost to follow-up. There was 1 cardiac death, 6 non-cardiac deaths and 4 MIs. Survival rates free of all-cause death, cardiac death and MACE at 10 years were 87%, 98% and 50%, respectively. The cumulative rates of TLR (TVR) were 16% (16%) at 1 year, 18% (22%) at 5 years and 28% (38%) at 10 years. Two definite scaffold thromboses (1 subacute, 1 very late) were recorded. The latter case was related to a sirolimus-eluting stent, which was implanted for a lesion proximal to an Igaki-Tamai stent. From the analysis of IVUS data, the stent struts mostly disappeared within 3 years. The external elastic membrane area and the stent area did not change. CONCLUSIONS: Acceptable MACE and scaffold thrombosis rates without stent recoil and vessel remodeling suggested the long-term safety of the Igaki-Tamai stent. |
| | |
Authors:
|
Soji Nishio; Kunihiko Kosuga; Keiji Igaki; Masaharu Okada; Eisho Kyo; Takafumi Tsuji; Eiji Takeuchi; Yasutaka Inuzuka; Shinsaku Takeda; Tatsuhiko Hata; Yuzo Takeuchi; Yoshitaka Kawada; Takeshi Harita; Junya Seki; Shunji Akamatsu; Shinichi Hasegawa; Nico Bruining; Salvatore Brugaletta; Sebastiaan de Winter; Takashi Muramatsu; Yoshinobu Onuma; Patrick W Serruys; Shigeru Ikeguchi |
Related Documents
:
|
22213795 - J-wave-associated ventricular fibrillation in a patient with a subarachnoid haemorrhage. 21474475 - Enhanced glucose uptake via glut4 fuels recovery from calcium overload after ischaemia-... 21825865 - False heart-to-mediastinum ratio of i-123 metaiodobenzylguanidine due to right ventricu... 22194765 - Drug-eluting stent as an option for intractable in-stent coronary restenosis. 10453605 - A comparative observation on treatment of heart failure due to diastolic insufficiency ... 2805705 - Energy value of glucose and lactate for the myocardium in patients with mitral stenosis. |
Publication Detail:
|
Type: JOURNAL ARTICLE Date: 2012-4-16 |
Journal Detail:
|
Title: Circulation Volume: - ISSN: 1524-4539 ISO Abbreviation: - Publication Date: 2012 Apr |
Date Detail:
|
Created Date: 2012-4-17 Completed Date: - Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 0147763 Medline TA: Circulation Country: - |
Other Details:
|
Languages: ENG Pagination: - Citation Subset: - |
Affiliation:
|
1 Shiga Medical Center for Adults, Shiga, Japan; |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
|
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: pIRS: Profile based Illumina pair-end Reads Simulator.
Next Document: The Disappearing Stent: When Plastic Replaces Metal.