| Long QT syndrome in patients over 40 years of age: increased risk for LQTS-related cardiac events in patients with coronary disease. | |
| | |
MedLine Citation:
|
PMID: 18973489 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
BACKGROUND: Previous studies of long QT syndrome (LQTS) have focused primarily on the clinical course of affected patients up to 40 years of age to avoid the confounding influence of acquired heart disease on LQTS-related cardiac events in this genetic disorder. METHODS: Patients were identified as having coronary disease if they had a history of hospitalization for myocardial infarction, coronary angioplasty, coronary artery bypass graft surgery, or were treated with medication for angina. LQTS-related cardiac events included the first occurrence of syncope, aborted cardiac arrest, or sudden cardiac death without evidence suggestive of an acute coronary event. Cox proportional hazards regression modeling was used to analyze the independent contribution of coronary disease to LQTS-related cardiac events. RESULTS: Time-dependent coronary disease was associated with an increased risk of LQTS-related cardiac events (hazard ratio 2.24, 95% confidence interval 1.23-4.07, P = 0.008) after adjustment for syncopal history before age 40, QTc, and gender. Factors such as diabetes and hypertension that increase the risk for coronary disease were not associated with an increased risk for LQTS-related cardiac events. CONCLUSIONS: This is the first study to demonstrate that coronary disease augments the risk for LQTS-related cardiac events in LQTS. The findings highlight the need for more focused preventive therapy in LQTS patients above the age of 40. |
| | |
Authors:
|
Edward Sze; Arthur J Moss; Ilan Goldenberg; Scott McNitt; Christian Jons; Wojciech Zareba; Ming Qi; Jennifer L Robinson; |
Related Documents
:
|
16990579 - Risk score for peri-interventional complications of carotid artery stenting. 8769919 - Indications for intensive care unit care after carotid endarterectomy. 19892239 - The coronary artery calcium score and stress myocardial perfusion imaging provide indep... 19758689 - Cardiac history and risk of post-cystectomy cardiac complications. 904659 - Multifactorial index of cardiac risk in noncardiac surgical procedures. 12430669 - A historical cohort study of the effect of lowering body iron through blood donation on... 7208359 - Short-lived radionuclides for the assessment of rapid cardiovascular drug effects. 6650949 - Left bundle branch block associated with propoxyphene hydrochloride poisoning. 6622339 - Left ventricular thrombi after acute myocardial infarction. |
Publication Detail:
|
Type: Journal Article; Multicenter Study; Research Support, N.I.H., Extramural |
Journal Detail:
|
Title: Annals of noninvasive electrocardiology : the official journal of the International Society for Holter and Noninvasive Electrocardiology, Inc Volume: 13 ISSN: 1542-474X ISO Abbreviation: Ann Noninvasive Electrocardiol Publication Date: 2008 Oct |
Date Detail:
|
Created Date: 2008-10-31 Completed Date: 2009-02-12 Revised Date: 2011-09-26 |
Medline Journal Info:
|
Nlm Unique ID: 9607443 Medline TA: Ann Noninvasive Electrocardiol Country: United States |
Other Details:
|
Languages: eng Pagination: 327-31 Citation Subset: IM |
Affiliation:
|
Cardiology Division, Department of Medicine, University of Rochester School of Medicine and Dentistry, Rochester, NY 14642-8653, USA. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Adrenergic beta-Antagonists
/
therapeutic use Adult Aged Aged, 80 and over Death, Sudden, Cardiac / etiology* Female Heart Arrest / etiology* Humans Long QT Syndrome / complications*, therapy Male Middle Aged Risk Factors Syncope / etiology* |
| Grant Support | |
ID/Acronym/Agency:
|
HL-33843/HL/NHLBI NIH HHS; HL-51618/HL/NHLBI NIH HHS; R01 HL033843-20A1/HL/NHLBI NIH HHS; R01 HL051618-10/HL/NHLBI NIH HHS |
| Chemical | |
Reg. No./Substance:
|
0/Adrenergic beta-Antagonists |
| Investigator | |
Investigator/Affiliation:
|
Michael J Ackerman / ; Jesaia Benhorin / ; Elizabeth Kaufman / ; Emanuela Locati / ; Carlo Napolitano / ; Silvia Priori / ; Peter J Schwartz / ; Carla Spazzolini / ; Jeffrey Towbin / ; G Michael Vincent / ; Li Zhang / |
| Comments/Corrections | |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Why does a method that fails continue to be used?
Next Document: The impact of the distance between the atrial electrode and the atrial wall on atrial undersensing i...