| Long QT syndrome and anaesthesia | |
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MedLine Citation:
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PMID: 16447035 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The long QT syndrome (LQTS) is a rare, congenital or acquired disease, which may lead to fatal cardiac arrhythmias (torsade de pointes, TdP). In all LQTS subtypes, TdPs are caused by disturbances in cardiac ion channels. Diagnosis is made using clinical, anamnestic and electrocardiographic data. Triggers of TdPs are numerous and should be avoided perioperatively. Sufficient sedation and preoperative correction of electrolyte imbalances are essential. Volatile anaesthetics and antagonists of muscle relaxants should be avoided and high doses of local anaesthetics are not recommended to date. Propofol is safe for anaesthesia induction and maintenance. The acute therapy of TdPs with cardiovascular depression should be performed in accordance with the guidelines for advanced cardiac life support and includes cardioversion/defibrillation and magnesium. Torsades de pointes may be associated with bradycardia or tachycardia resulting in specific therapeutic and prophylactic measures. |
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Authors:
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S Rasche; T Koch; M Hübler |
Publication Detail:
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Type: English Abstract; Journal Article; Review |
Journal Detail:
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Title: Der Anaesthesist Volume: 55 ISSN: 1432-055X ISO Abbreviation: Anaesthesist Publication Date: 2006 Mar |
Date Detail:
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Created Date: 2006-03-24 Completed Date: 2009-02-06 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 0370525 Medline TA: Anaesthesist Country: Germany |
Other Details:
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Languages: ger Pagination: 229-46 Citation Subset: IM |
Affiliation:
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Klinik und Poliklinik für Anästhesiologie und Intensivtherapie, Universitätsklinikum Carl Gustav Carus, Technische Universität, Dresden. Stefan.Rasche@uniklinikum-dresden.de |
Vernacular Title:
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Das Long-QT-Syndrom in der Anästhesie. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Action Potentials
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drug effects,
physiology Anesthesia / adverse effects* Anesthetics / adverse effects Anesthetics, Inhalation / adverse effects Anesthetics, Intravenous / adverse effects Electrocardiography / drug effects Humans Ion Channels / drug effects, physiology Long QT Syndrome / chemically induced*, diagnosis, genetics, prevention & control, therapy Torsades de Pointes / chemically induced, physiopathology |
| Chemical | |
Reg. No./Substance:
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0/Anesthetics; 0/Anesthetics, Inhalation; 0/Anesthetics, Intravenous; 0/Ion Channels |
| Comments/Corrections | |
Comment In:
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Anaesthesist. 2006 Sep;55(9):1006-7; author reply 1007-8
[PMID:
16897019
]
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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