| Long QT syndrome in African-Americans. | |
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MedLine Citation:
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PMID: 20146785 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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BACKGROUND: We evaluated the risk factors and clinical course of Long QT syndrome (LQTS) in African-American patients. METHODS: The study involved 41 African-Americans and 3456 Caucasians with a QTc > or = 450 ms from the U.S. portion of the International LQTS Registry. Data included information about the medical history and clinical course of the LQTS patients with end points relating to the occurrence of syncope, aborted cardiac arrest, or LQTS-related sudden cardiac death from birth through age 40 years. The statistical analyses involved Kaplan-Meier time to event graphs and Cox regression models for multivariable risk factor evaluation. RESULTS: The QTc was 29 ms longer in African-Americans than Caucasians. Multivarite Cox analyses with adjustment for decade of birth revealed that the cardiac event rate was similar in African-Americans and Caucasians with LQTS and that beta-blockers were equally effective in reducing cardiac events in the two racial groups. CONCLUSIONS: The clinical course of LQTS in African-Americans is similar to that of Caucasians with comparable risk factors and benefit from beta-blocker therapy in the two racial groups. |
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Authors:
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Thomas Fugate; Arthur J Moss; Christian Jons; Scott McNitt; Jamie Mullally; Gregory Ouellet; Ilan Goldenberg; Wojciech Zareba; Jennifer L Robinson; |
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Publication Detail:
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Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Annals of noninvasive electrocardiology : the official journal of the International Society for Holter and Noninvasive Electrocardiology, Inc Volume: 15 ISSN: 1542-474X ISO Abbreviation: Ann Noninvasive Electrocardiol Publication Date: 2010 Jan |
Date Detail:
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Created Date: 2010-02-11 Completed Date: 2010-05-27 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9607443 Medline TA: Ann Noninvasive Electrocardiol Country: United States |
Other Details:
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Languages: eng Pagination: 73-6 Citation Subset: IM |
Affiliation:
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Cardiology Division of the Department of Medicine, University of Rochester School of Medicine and Dentistry, Rochester, NY 14642-8653, USA. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adolescent Adrenergic beta-Antagonists / therapeutic use Adult African Americans / statistics & numerical data* Age Distribution Child Child, Preschool Death, Sudden, Cardiac / epidemiology European Continental Ancestry Group / statistics & numerical data Female Heart Arrest / drug therapy, epidemiology Humans Infant Infant, Newborn Kaplan-Meiers Estimate Long QT Syndrome / drug therapy, epidemiology* Male Proportional Hazards Models Registries Risk Factors Syncope / drug therapy, epidemiology United States / epidemiology Young Adult |
| Grant Support | |
ID/Acronym/Agency:
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HL-33843/HL/NHLBI NIH HHS; HL-51618/HL/NHLBI NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/Adrenergic beta-Antagonists |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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