Document Detail


Long Non-coding RNAs Involved in Cancer Development and Cell Fate Determination.
MedLine Citation:
PMID:  22974399     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
The possible physiological significance of long non-coding RNAs (lncRNAs) has only recently been recognized. Technical innovations such as the super high-resolution tiling array and deep sequencing technology have indicated their importance. It has been proposed that lncRNAs such as HOTAIR are involved in the recruitment of chromatin modifiers to the target genes. The lncRNA ANRIL has been reported to be associated with a Polycomb complex, recruiting it to the target gene INK4 locus where it suppresses transcription via histone modification. Other lncRNAs such as Kcnq1ot1, AIR and Xist have also been found to recruit chromatin modifiers to their target loci. In this review, we discuss the function of lncRNAs such as HOTAIR, ANRIL, Kcnq1ot1, and Xist which recruit chromatin modifiers to target genes and discuss their involvement in cancer development and aggressiveness, and other cell fate determination.
Authors:
Masatoshi Kitagawa; Yojiro Kotake; Tatsuya Ohhata
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2012-9-07
Journal Detail:
Title:  Current drug targets     Volume:  -     ISSN:  1873-5592     ISO Abbreviation:  Curr Drug Targets     Publication Date:  2012 Sep 
Date Detail:
Created Date:  2012-9-14     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  100960531     Medline TA:  Curr Drug Targets     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Affiliation:
Department of Molecular Biology, Hamamatsu University School of Medicine 1-20-1 Handayama, Higashi-ku, Hamamatsu 431-3125, Japan. kitamasa@hama-med.ac.jp.
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