Document Detail

Long-Living Intermediates during a Lamellar to a Diamond-Cubic Lipid Phase Transition: A Small-Angle X-Ray Scattering Investigation.
MedLine Citation:
PMID:  19222217     Owner:  NLM     Status:  Publisher    
To generate nanostructured vehicles with tunable internal organization, the structural phase behavior of a self-assembled amphiphilic mixture involving poly(ethylene glycol) monooleate (MO-PEG) and glycerol monooleate (MO) is studied in excess aqueous medium by time-resolved small-angle X-ray scattering (SAXS) in the temperature range from 1 to 68 degrees C. The SAXS data indicate miscibility of the two components in lamellar and nonlamellar soft-matter nanostructures. The functionalization of the MO assemblies by a MO-PEG amphiphile, which has a flexible large hydrophilic moiety, appears to hinder the epitaxial growth of a double diamond (D) cubic lattice from the lamellar (L) bilayer structure during the thermal phase transition. The incorporated MO-PEG additive is found to facilitate the formation of structural intermediates. They exhibit greater characteristic spacings and large diffusive scattering in broad temperature and time intervals. Their features are compared with those of swollen long-living intermediates in MO/octylglucoside assemblies. A conclusion can be drawn that long-living intermediate states can be equilibrium stabilized in two- or multicomponent amphiphilic systems. Their role as cubic phase precursors is to smooth the structural distortions arising from curvature mismatch between flat and curved regions. The considered MO-PEG functionalized assemblies may be useful for preparation of sterically stabilized liquid-crystalline nanovehicles for confinement of therapeutic biomolecules.
Borislav Angelov; Angelina Angelova; Ulla Vainio; Vasil M Garamus; Sylviane Lesieur; Regine Willumeit; Patrick Couvreur
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2009-2-17
Journal Detail:
Title:  Langmuir : the ACS journal of surfaces and colloids     Volume:  -     ISSN:  1520-5827     ISO Abbreviation:  Langmuir     Publication Date:  2009 Feb 
Date Detail:
Created Date:  2009-2-18     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9882736     Medline TA:  Langmuir     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Institute of Biophysics, Bulgarian Academy of Sciences, BG-1113 Sofia, Bulgaria, CNRS UMR8612 Physico-chimie-Pharmacotechnie-Biopharmacie, Chatenay-Malabry, F-92296 France, University Paris Sud, Chatenay-Malabry, F-92296 France, Institute of Materials Research, GKSS Research Center, Geesthacht, D-21502 Germany, and HASYLAB c/o DESY, Notkestrasse 85, Hamburg, D-22603 Germany.
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