| Long-Lasting Tumor Response in Patients with Panitumumab Monotherapy for Chemorefractory Metastatic Colorectal Carcinoma - A Report of Two Cases. | |
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MedLine Citation:
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PMID: 20740189 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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BACKGROUND: Second as well as higher-line therapies have a significant influence on progression-free and overall survival of metastatic colorectal cancer patients. However, treatment of late-stage disease remains suboptimal. Therefore, the introduction of new, effective and well-tolerated agents is of major importance. Case Reports: Here we describe the cases of 2 patients with metastatic KRAS wild-type colorectal cancer who received a fourth-line monotherapy with panitumumab after failure of 5-fluorouracil, irinotecan, oxaliplatin, and bevacizumab. RESULTS: Both patients achieved a partial remission, and for 11.5 and 18 months, respectively, they had a stable disease with initial reduction in the tumor marker carcinoembryonic antigen. Both patients reported a good tolerability of the treatment with improved quality of life (compared to receiving combined chemotherapy). CONCLUSION: Panitumumab monotherapy is an effective and well tolerated treatment of metastatic colorectal cancer in extensively pretreated KRAS wild-type patients. Our data have shown a response to panitumumab monotherapy for more than 11 months. |
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Authors:
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G Ramadori; S Cameron; B Tschechne |
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Publication Detail:
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Type: JOURNAL ARTICLE Date: 2010-5-07 |
Journal Detail:
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Title: Case reports in oncology Volume: 3 ISSN: 1662-6575 ISO Abbreviation: - Publication Date: 2010 |
Date Detail:
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Created Date: 2010-8-26 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 101517601 Medline TA: Case Rep Oncol Country: - |
Other Details:
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Languages: ENG Pagination: 154-159 Citation Subset: - |
Affiliation:
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Department for Gastroenterology and Endocrinology, University Medicine Göttingen, Göttingen, Germany. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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