Document Detail


Long-chain polyunsaturated fatty acid supplementation in infancy reduces heart rate and positively affects distribution of attention.
MedLine Citation:
PMID:  21705959     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
A double-blind, randomized, controlled, parallel-group prospective trial was conducted to determine whether a dose-response existed for four different levels of docosahexaenoic acid (DHA) supplementation on the cognitive performance of infants. A total of 122 term infants were fed one of four different formulas varying in their DHA composition (0.00, 0.32, 0.64, and 0.96% of total fatty acids as DHA) from birth to 12 mo. The three DHA-supplemented formulas also contained 0.64% of total fatty acids as arachidonic acid (ARA, 20:4n-6). Infants were tested at 4, 6, and 9 mo of age on a visual habituation protocol that yielded both behavioral and psychophysiological indices of attention. Infants in all DHA+ARA-supplemented conditions had lower heart rates than those in the unsupplemented condition; there was no dose-response for this effect. The distribution of time that infants spent in different phases of attention (a cognitive index derived from the convergence of behavioral and cardiac responses) varied as a function of dosage. Infants supplemented at the two lower DHA doses spent proportionately more time engaged in active stimulus processing than infants fed the unsupplemented formula, whereas infants fed the highest dose were intermediate and did not differ from any other group.
Authors:
John Colombo; Susan E Carlson; Carol L Cheatham; Kathleen M Fitzgerald-Gustafson; Amy Kepler; Tasha Doty
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Publication Detail:
Type:  Journal Article; Randomized Controlled Trial; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Pediatric research     Volume:  70     ISSN:  1530-0447     ISO Abbreviation:  Pediatr. Res.     Publication Date:  2011 Oct 
Date Detail:
Created Date:  2011-09-02     Completed Date:  2011-12-19     Revised Date:  2013-12-11    
Medline Journal Info:
Nlm Unique ID:  0100714     Medline TA:  Pediatr Res     Country:  United States    
Other Details:
Languages:  eng     Pagination:  406-10     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Animals
Attention / drug effects*
Dietary Supplements*
Docosahexaenoic Acids / administration & dosage*
Double-Blind Method
Fatty Acids, Unsaturated / administration & dosage*
Heart Rate / drug effects*
Humans
Infant
Infant Formula / chemistry
Neuropsychological Tests
Prospective Studies
Grant Support
ID/Acronym/Agency:
P30 HD002528/HD/NICHD NIH HHS; P30 HD002528-43/HD/NICHD NIH HHS; R01 HD047315/HD/NICHD NIH HHS; R01 HD047315/HD/NICHD NIH HHS; R01 HD047315-01A2/HD/NICHD NIH HHS
Chemical
Reg. No./Substance:
0/Fatty Acids, Unsaturated; 25167-62-8/Docosahexaenoic Acids
Comments/Corrections

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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