| Long-chain polyunsaturated fatty acid composition of breast milk in pre-eclamptic mothers. | |
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MedLine Citation:
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PMID: 19864925 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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BACKGROUND: Maternal fatty acid nutrition during pregnancy and lactation determines the transfer of long-chain polyunsaturated fatty acids via the placenta and through human milk. Neural maturation of breast-fed infants is known to be linked to breast-milk long-chain polyunsaturated fatty acid concentrations. In spite of this, the fatty acid composition of breast milk in pre-eclamptic mothers is poorly understood. OBJECTIVES: To compare the fatty acid composition of breast milk of pre-eclamptic (n = 45) with normotensive (n = 85) mothers and examine the association of breast-milk fatty acids with plasma fatty acids. METHODS: Milk and plasma fatty acid methyl esters were prepared and analyzed by the modified method of Manku and colleagues using gas chromatography. RESULTS: Docosahexaenoic acid (DHA) concentrations were significantly increased (p < 0.01) in breast milk in spite of lower maternal plasma DHA concentrations (p < 0.05) in pre-eclamptic women. However, there was no difference in arachidonic acid levels between groups in spite of reduced maternal plasma arachidonic acid levels. CONCLUSIONS: The data suggest that in pre-eclampsia, the relation between plasma and milk DHA is altered. The resulting higher milk DHA concentrations are beneficial for infants. |
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Authors:
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Kamini D Dangat; Savita S Mehendale; Hemlata R Yadav; Anitha S Kilari; Asmita V Kulkarni; Vaishali S Taralekar; Sadhana R Joshi |
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Publication Detail:
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Type: Comparative Study; Journal Article Date: 2009-10-28 |
Journal Detail:
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Title: Neonatology Volume: 97 ISSN: 1661-7819 ISO Abbreviation: Neonatology Publication Date: 2010 |
Date Detail:
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Created Date: 2010-03-24 Completed Date: 2010-08-06 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 101286577 Medline TA: Neonatology Country: Switzerland |
Other Details:
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Languages: eng Pagination: 190-4 Citation Subset: IM |
Copyright Information:
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Copyright 2009 S. Karger AG, Basel. |
Affiliation:
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Department of Nutritional Medicine, Interactive Research School for Health Affairs, Dhankawadi Campus, Pune 411043, India. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adult Birth Weight / physiology Blood Pressure / physiology Body Weight / physiology Cohort Studies Fatty Acids, Unsaturated / analysis*, blood, metabolism Female Humans Infant, Newborn Metabolome Milk, Human / chemistry*, metabolism Pre-Eclampsia / blood, metabolism*, physiopathology Pregnancy Young Adult |
| Chemical | |
Reg. No./Substance:
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0/Fatty Acids, Unsaturated |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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