Document Detail


Long-chain polyunsaturated fatty acid composition of breast milk in pre-eclamptic mothers.
MedLine Citation:
PMID:  19864925     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
BACKGROUND: Maternal fatty acid nutrition during pregnancy and lactation determines the transfer of long-chain polyunsaturated fatty acids via the placenta and through human milk. Neural maturation of breast-fed infants is known to be linked to breast-milk long-chain polyunsaturated fatty acid concentrations. In spite of this, the fatty acid composition of breast milk in pre-eclamptic mothers is poorly understood. OBJECTIVES: To compare the fatty acid composition of breast milk of pre-eclamptic (n = 45) with normotensive (n = 85) mothers and examine the association of breast-milk fatty acids with plasma fatty acids. METHODS: Milk and plasma fatty acid methyl esters were prepared and analyzed by the modified method of Manku and colleagues using gas chromatography. RESULTS: Docosahexaenoic acid (DHA) concentrations were significantly increased (p < 0.01) in breast milk in spite of lower maternal plasma DHA concentrations (p < 0.05) in pre-eclamptic women. However, there was no difference in arachidonic acid levels between groups in spite of reduced maternal plasma arachidonic acid levels. CONCLUSIONS: The data suggest that in pre-eclampsia, the relation between plasma and milk DHA is altered. The resulting higher milk DHA concentrations are beneficial for infants.
Authors:
Kamini D Dangat; Savita S Mehendale; Hemlata R Yadav; Anitha S Kilari; Asmita V Kulkarni; Vaishali S Taralekar; Sadhana R Joshi
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Publication Detail:
Type:  Comparative Study; Journal Article     Date:  2009-10-28
Journal Detail:
Title:  Neonatology     Volume:  97     ISSN:  1661-7819     ISO Abbreviation:  Neonatology     Publication Date:  2010  
Date Detail:
Created Date:  2010-03-24     Completed Date:  2010-08-06     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101286577     Medline TA:  Neonatology     Country:  Switzerland    
Other Details:
Languages:  eng     Pagination:  190-4     Citation Subset:  IM    
Copyright Information:
Copyright 2009 S. Karger AG, Basel.
Affiliation:
Department of Nutritional Medicine, Interactive Research School for Health Affairs, Dhankawadi Campus, Pune 411043, India.
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MeSH Terms
Descriptor/Qualifier:
Adult
Birth Weight / physiology
Blood Pressure / physiology
Body Weight / physiology
Cohort Studies
Fatty Acids, Unsaturated / analysis*,  blood,  metabolism
Female
Humans
Infant, Newborn
Metabolome
Milk, Human / chemistry*,  metabolism
Pre-Eclampsia / blood,  metabolism*,  physiopathology
Pregnancy
Young Adult
Chemical
Reg. No./Substance:
0/Fatty Acids, Unsaturated

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