Document Detail


Lomefloxacin, a new fluoroquinolone. Studies on in vitro antimicrobial spectrum, potency, and development of resistance.
MedLine Citation:
PMID:  2791485     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Lomefloxacin (NY-198; SC-47111), a potent new difluoroquinolone, was studied to compare its in vitro activity with that of other antimicrobials against 2194 clinical isolates. Lomefloxacin showed excellent inhibitory and bactericidal activity against strains of Enterobacteriaceae and inhibited greater than 99% of the isolates at a concentration of 4 micrograms/ml or less. Lomefloxacin exhibited good-to-moderate activity against strains of Acinetobacter (MIC90 4 micrograms/ml) and Pseudomonas aeruginosa (MIC90 8 micrograms/ml), but poor activity for Pseudomonas cepacia (MIC90 greater than 16 micrograms/ml). Staphylococcus aureus, and Staphylococcus epidermidis isolates, both oxacillin-susceptible and -resistant strains, were susceptible (MIC90 1 micrograms/ml) to lomefloxacin and the other fluoroquinolones. Strains of Haemophilus influenzae, (MIC90 less than or equal to 0.13 micrograms/ml) Neisseria gonorrhoeae (MIC90 less than or equal to 0.03 micrograms/ml), and Branhamella catarrhalis (MIC90 less than or equal to 0.03 micrograms/ml) were highly susceptible to lomefloxacin. Streptococcal isolates, especially viridans streptococci, were considerably less susceptible to the fluoroquinolones. Overall, lomefloxacin had comparable activity to norfloxacin, fleroxacin, and ofloxacin, and against many facultative anaerobes lomefloxacin was more active than imipenem, cefotaxime, ceftazidime, ticarcillin/clavulanic acid, aztreonam, trimethoprim/sulfamethoxazole and gentamicin. Development of resistance to lomefloxacin by spontaneous mutation was low and comparable to that of other fluoroquinolones. Growth in subinhibitory concentrations resulted in increased resistance to fluoroquinolones for selected test strains.
Authors:
K E Aldridge; A Henderberg; K Gebbia; D D Schiro; A Janney; C V Sanders
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Diagnostic microbiology and infectious disease     Volume:  12     ISSN:  0732-8893     ISO Abbreviation:  Diagn. Microbiol. Infect. Dis.     Publication Date:    1989 May-Jun
Date Detail:
Created Date:  1989-11-02     Completed Date:  1989-11-02     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  8305899     Medline TA:  Diagn Microbiol Infect Dis     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  221-33     Citation Subset:  IM    
Affiliation:
Department of Medicine Center, New Orleans 70112.
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MeSH Terms
Descriptor/Qualifier:
4-Quinolones
Anti-Infective Agents / pharmacology*
Bacteria / drug effects*
Drug Resistance, Microbial / genetics
Fluoroquinolones*
Microbial Sensitivity Tests
Mutation
Quinolones*
Chemical
Reg. No./Substance:
0/4-Quinolones; 0/Anti-Infective Agents; 0/Fluoroquinolones; 0/Quinolones; 98079-51-7/lomefloxacin

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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