Document Detail


Loihichelins A-F, a suite of amphiphilic siderophores produced by the marine bacterium Halomonas LOB-5.
MedLine Citation:
PMID:  19320498     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
A suite of amphiphilic siderophores, loihichelins A-F, were isolated from cultures of the marine bacterium Halomonas sp. LOB-5. This heterotrophic Mn(II)-oxidizing bacterium was recently isolated from the partially weathered surfaces of submarine glassy pillow basalts and associated hydrothermal flocs of iron oxides collected from the southern rift zone of Loihi Seamount east of Hawai'i. The loihichelins contain a hydrophilic headgroup consisting of an octapeptide comprised of D-threo-beta-hydroxyaspartic acid, D-serine, L-glutamine, L-serine, L-N(delta)-acetyl-N(delta)-hydroxyornithine, dehydroamino-2-butyric acid, D-serine, and cyclic N(delta)-hydroxy-D-ornithine, appended by one of a series of fatty acids ranging from decanoic acid to tetradecanoic acid. The structure of loihichelin C was determined by a combination of amino acid and fatty acid analyses, tandem mass spectrometry, and NMR spectroscopy. The structures of the other loihichelins were inferred from the amino acid and fatty acid analyses and tandem mass spectrometry. The role of these siderophores in sequestering Fe(III) released during basaltic rock weathering, as well as their potential role in the promotion of Mn(II) and Fe(II) oxidation, is of considerable interest.
Authors:
Vanessa V Homann; Moriah Sandy; J Andy Tincu; Alexis S Templeton; Bradley M Tebo; Alison Butler
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.    
Journal Detail:
Title:  Journal of natural products     Volume:  72     ISSN:  1520-6025     ISO Abbreviation:  J. Nat. Prod.     Publication Date:  2009 May 
Date Detail:
Created Date:  2010-06-21     Completed Date:  2010-07-20     Revised Date:  2013-06-02    
Medline Journal Info:
Nlm Unique ID:  7906882     Medline TA:  J Nat Prod     Country:  United States    
Other Details:
Languages:  eng     Pagination:  884-8     Citation Subset:  IM    
Affiliation:
Department of Chemistry and Biochemistry, University of California, Santa Barbara, California 93106-9510, USA.
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MeSH Terms
Descriptor/Qualifier:
Halomonas / chemistry*
Iron / metabolism
Manganese / metabolism
Marine Biology
Molecular Structure
Nuclear Magnetic Resonance, Biomolecular
Oligopeptides / chemistry,  isolation & purification*
Oxidation-Reduction
Siderophores / chemistry,  isolation & purification*
Grant Support
ID/Acronym/Agency:
GM38130/GM/NIGMS NIH HHS; R01 GM038130-15/GM/NIGMS NIH HHS; R01 GM038130-16/GM/NIGMS NIH HHS
Chemical
Reg. No./Substance:
0/Oligopeptides; 0/Siderophores; 7439-89-6/Iron; 7439-96-5/Manganese
Comments/Corrections

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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