Document Detail

Logarithmic curves depicting initial level and rise of serum beta human chorionic gonadotropin and live delivery outcomes with in vitro fertilization: an analysis of 6021 pregnancies.
MedLine Citation:
PMID:  18455162     Owner:  NLM     Status:  MEDLINE    
OBJECTIVE: To correlate the live delivery rate with the initial level and rise of serum beta-hCG. DESIGN: Retrospective cohort analysis. SETTING: Large private academic center for assisted reproductive technologies and infertility. PATIENT(S): Records of all patients from 1999 to 2005 undergoing IVF with detectable early serum beta-hCG after ET. INTERVENTION(S): None. MAIN OUTCOME MEASURE(S): Live delivery rate. RESULT(S): Data from 6021 pregnancies were analyzed. Initial beta-hCG was predictive for delivery rate for all patients and for each age group. After controlling for the first beta-hCG, there were higher loss rates as age increased. Percent rise in second beta-hCG drawn 2 days later added predictive value. A decline in beta-hCG almost always resulted in a failure to deliver. There was a progressive increase in delivery rate as the percent rise in beta-hCG went from 0 to 100%; however, there was no further enhancement in delivery rates beyond the 100% rise point. While a better rise in beta-hCG was a good prognostic factor in all age groups, the differences in outcomes for the different age groups remained, even after controlling for first beta-hCG and percent rise. CONCLUSION(S): Initial level and rise in beta-hCG predicts live delivery rate, with oocyte age providing additional predictive value. The established logarithmic curves should provide convenient reference tools for tracking outcomes and counseling patients.
Mousa I Shamonki; John L Frattarelli; Paul A Bergh; Richard T Scott
Publication Detail:
Type:  Journal Article     Date:  2008-05-02
Journal Detail:
Title:  Fertility and sterility     Volume:  91     ISSN:  1556-5653     ISO Abbreviation:  Fertil. Steril.     Publication Date:  2009 May 
Date Detail:
Created Date:  2009-05-07     Completed Date:  2009-05-19     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0372772     Medline TA:  Fertil Steril     Country:  United States    
Other Details:
Languages:  eng     Pagination:  1760-4     Citation Subset:  IM    
Division of Reproductive Endocrinology and Infertility, University of California-Los Angeles, Los Angeles, California, USA.
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MeSH Terms
Chorionic Gonadotropin, beta Subunit, Human / blood*
Cohort Studies
Fertilization in Vitro*
Pregnancy Outcome
Pregnancy Rate
Retrospective Studies
Reg. No./Substance:
0/Chorionic Gonadotropin, beta Subunit, Human

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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