Document Detail

Lofepramine in the elderly.
MedLine Citation:
PMID:  3063744     Owner:  NLM     Status:  MEDLINE    
Depression prevails in 12-13% of the elderly, of whom a 5th suffer major depressive illness. First admission-rates to psychiatric beds in England increase with aging until the 80s, when they fall off in women but continue to rise in men. Physical illness is a considerable contributor to depression in old age, and consequently depression is more prevalent in elderly general hospital inpatients than in the community. Better screening instruments are needed to detect this depression, and the place of antidepressant therapy needs to be better established. All antidepressants fall short of the ideal, particularly through acting slowly, having side-effects and being dangerous in overdose. Justifiably popular though dothiepin is in the treatment of depression in the elderly, its fatal toxicity index is high. Lofepramine appears to be as effective, to have fewer side-effects and to be safer, but experience of it is relatively meagre in the elderly and satisfactory double-blind comparisons with suitable control drugs in this age group have yet to be reported. If it lives up to its present promise it may be particularly suitable for the physically ill and depressed elderly.
B M Pitt
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Publication Detail:
Type:  Comparative Study; Journal Article; Review    
Journal Detail:
Title:  International clinical psychopharmacology     Volume:  3 Suppl 2     ISSN:  0268-1315     ISO Abbreviation:  Int Clin Psychopharmacol     Publication Date:  1988 Nov 
Date Detail:
Created Date:  1989-03-09     Completed Date:  1989-03-09     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  8609061     Medline TA:  Int Clin Psychopharmacol     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  49-54     Citation Subset:  IM    
St Mary's Hospital, London, England.
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MeSH Terms
Adjustment Disorders / drug therapy
Depressive Disorder / drug therapy*
Dibenzazepines / therapeutic use*
Lofepramine / adverse effects,  therapeutic use*
Reg. No./Substance:
0/Dibenzazepines; 23047-25-8/Lofepramine

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