Document Detail

Loeffler endocarditis: what have we learned?
MedLine Citation:
PMID:  17573694     Owner:  NLM     Status:  MEDLINE    
Loeffler endocarditis, eosinophilic endomyocardial disease or fibroplastic endocarditis appears to be a subcategory of the Hypereosinophilic syndrome in which the heart is predominantly involved. It is an uncommon myocardial disease, thought to be secondary to eosinophils damage, characterized by fibrous thickening of the endocardium of one or both ventricles, leading to apical obliteration and multiple cardiovascular complications. Despite all the efforts, the ultimate responsible mechanisms of this entity remain unresolved. Many theories have been raised trying to explain this phenomenon, but nowadays the enigma in relation to the different patterns of evolution continues. In this concise review we discuss the different pathophysiologic theories postulated and the management of the cardiovascular complications. Perhaps it will serve to assist in recognition of patients with the same condition around the world.
Juan Benezet-Mazuecos; Adolfo de la Fuente; Pedro Marcos-Alberca; Jeronimo Farre
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Publication Detail:
Type:  Comment; Journal Article    
Journal Detail:
Title:  American journal of hematology     Volume:  82     ISSN:  0361-8609     ISO Abbreviation:  Am. J. Hematol.     Publication Date:  2007 Oct 
Date Detail:
Created Date:  2007-09-17     Completed Date:  2007-11-08     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  7610369     Medline TA:  Am J Hematol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  861-2     Citation Subset:  IM    
Department of Cardiology, Fundación Jiménez Díaz, Universidad Autónoma de Madrid, Madrid, Spain.
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MeSH Terms
Cardiovascular Agents / therapeutic use
Heart Failure / drug therapy,  etiology
Hypereosinophilic Syndrome / complications,  drug therapy,  physiopathology*
Models, Biological
Piperazines / therapeutic use
Pyrimidines / therapeutic use
Reg. No./Substance:
0/Cardiovascular Agents; 0/Piperazines; 0/Pyrimidines; 152459-95-5/imatinib
Comment On:
Am J Hematol. 2007 Oct;82(10):920-3   [PMID:  17534930 ]

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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