Document Detail

Locoregional intra-arterial therapies for unresectable intrahepatic cholangiocarcinoma.
MedLine Citation:
PMID:  20494703     Owner:  NLM     Status:  MEDLINE    
Intrahepatic cholangiocarcinoma (ICC) is a rare hepatic malignancy that for patients with unresectable disease is uniformly fatal. Only approximately 30% of patients are eligible for resection because of the advanced nature of the disease at the time of diagnosis. Systemic chemotherapy has been disappointing in regard to its efficacy, with most regimens resulting in a median survival of 6 to12 months. There has been great interest in other modalities of treatment, particularly intra-arterial therapies, which consist of a catheter-based group of treatments where therapeutic and/or embolic agents are intra-arterially injected to target the liver tumors. In this report, we attempt to employ an evidence-based approach to critically review and comprehend the current role and future potential of intra-arterial therapies for ICC.
Kelvin Hong; Jean-Francois H Geschwind
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Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  Seminars in oncology     Volume:  37     ISSN:  1532-8708     ISO Abbreviation:  Semin. Oncol.     Publication Date:  2010 Apr 
Date Detail:
Created Date:  2010-05-24     Completed Date:  2010-06-14     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0420432     Medline TA:  Semin Oncol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  110-7     Citation Subset:  IM    
Copyright Information:
Copyright 2010 Elsevier Inc. All rights reserved.
The Russell H. Morgan Department of Radiology and Radiological Science, Division of Vascular and Interventional Radiology, The Johns Hopkins University School of Medicine, Baltimore, MD, USA.
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MeSH Terms
Antineoplastic Agents / administration & dosage*,  adverse effects
Bile Duct Neoplasms / therapy*
Bile Ducts, Intrahepatic / drug effects,  pathology*,  radiation effects
Cholangiocarcinoma / therapy*
Embolization, Therapeutic* / methods
Infusions, Intra-Arterial* / methods
Radiotherapy / methods
Reg. No./Substance:
0/Antineoplastic Agents

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