| Locoregional intra-arterial therapies for unresectable intrahepatic cholangiocarcinoma. | |
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MedLine Citation:
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PMID: 20494703 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Intrahepatic cholangiocarcinoma (ICC) is a rare hepatic malignancy that for patients with unresectable disease is uniformly fatal. Only approximately 30% of patients are eligible for resection because of the advanced nature of the disease at the time of diagnosis. Systemic chemotherapy has been disappointing in regard to its efficacy, with most regimens resulting in a median survival of 6 to12 months. There has been great interest in other modalities of treatment, particularly intra-arterial therapies, which consist of a catheter-based group of treatments where therapeutic and/or embolic agents are intra-arterially injected to target the liver tumors. In this report, we attempt to employ an evidence-based approach to critically review and comprehend the current role and future potential of intra-arterial therapies for ICC. |
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Authors:
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Kelvin Hong; Jean-Francois H Geschwind |
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Publication Detail:
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Type: Journal Article; Review |
Journal Detail:
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Title: Seminars in oncology Volume: 37 ISSN: 1532-8708 ISO Abbreviation: Semin. Oncol. Publication Date: 2010 Apr |
Date Detail:
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Created Date: 2010-05-24 Completed Date: 2010-06-14 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 0420432 Medline TA: Semin Oncol Country: United States |
Other Details:
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Languages: eng Pagination: 110-7 Citation Subset: IM |
Copyright Information:
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Copyright 2010 Elsevier Inc. All rights reserved. |
Affiliation:
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The Russell H. Morgan Department of Radiology and Radiological Science, Division of Vascular and Interventional Radiology, The Johns Hopkins University School of Medicine, Baltimore, MD, USA. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Antineoplastic Agents
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administration & dosage*,
adverse effects Bile Duct Neoplasms / therapy* Bile Ducts, Intrahepatic / drug effects, pathology*, radiation effects Cholangiocarcinoma / therapy* Embolization, Therapeutic* / methods Humans Infusions, Intra-Arterial* / methods Radiotherapy / methods |
| Chemical | |
Reg. No./Substance:
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0/Antineoplastic Agents |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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