Document Detail


Locomotor stereotypy is produced by methylphenidate and amfonelic acid and reduced by haloperidol but not clozapine or thioridazine.
MedLine Citation:
PMID:  8100075     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
In addition to its well-known behavioral effects in rats, amphetamine also produces patterned locomotion (referred to below as locomotor stereotypy) in an open field. Locomotor stereotypy may be mediated by different mechanisms than those mediating the better-known behavioral effects of amphetamine. To determine whether the ability to produce locomotor stereotypy is an exclusive property of amphetamine or is a property of many amphetamine-like stimulants, several doses of methylphenidate and amfonelic acid were tested. The ability of both atypical and typical neuroleptics to block amphetamine-induced locomotor stereotypy was also tested. Both amfonelic acid and methylphenidate produced some degree of locomotor stereotypy. In addition, amphetamine-induced locomotor stereotypy was reduced by haloperidol but not by clozapine or thioridazine. These data suggest that locomotor stereotypy is more closely related to focused stereotypy than to hyperlocomotion.
Authors:
K Mueller
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Publication Detail:
Type:  Journal Article; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Pharmacology, biochemistry, and behavior     Volume:  45     ISSN:  0091-3057     ISO Abbreviation:  Pharmacol. Biochem. Behav.     Publication Date:  1993 May 
Date Detail:
Created Date:  1993-07-19     Completed Date:  1993-07-19     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  0367050     Medline TA:  Pharmacol Biochem Behav     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  71-6     Citation Subset:  IM    
Affiliation:
Department of Psychology, Texas Christian University, Fort Worth 76129.
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MeSH Terms
Descriptor/Qualifier:
Animals
Antipsychotic Agents / pharmacology*
Clozapine / pharmacology
Haloperidol / pharmacology
Male
Methylphenidate / antagonists & inhibitors,  pharmacology*
Motor Activity / drug effects*
Naphthyridines / antagonists & inhibitors,  pharmacology*
Rats
Rats, Wistar
Stereotyped Behavior / drug effects*
Thioridazine / pharmacology
Grant Support
ID/Acronym/Agency:
R01DA5817/DA/NIDA NIH HHS
Chemical
Reg. No./Substance:
0/Antipsychotic Agents; 0/Naphthyridines; 113-45-1/Methylphenidate; 15180-02-6/amfonelic acid; 50-52-2/Thioridazine; 52-86-8/Haloperidol; 5786-21-0/Clozapine

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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