Document Detail

Locomotor and exploratory behavior in the rat following bilateral vestibular deafferentation.
MedLine Citation:
PMID:  18410183     Owner:  NLM     Status:  MEDLINE    
Despite many studies of the postural and ocular reflex deficits caused by chronic bilateral vestibular loss in rats and guinea pigs, there have been few systematic studies of the effects of vestibular loss on locomotor activity and exploratory behavior over a period of several months following the lesion. In this study, the authors quantified locomotor and exploratory behavior in an open field maze at 3 weeks, 3 months, and 5 months following bilateral vestibular loss in rats. As a result of bilateral surgical vestibular lesions, rats exhibited a persistent increase in locomotor velocity, duration, and distance traveled, with a marked tendency for increased inner field activity and reduced thigmotaxis. Rats without balance-sense were also found to spend less time exploring the environment, as indicated by a decreased frequency and duration of wall-supported rearings. These results suggest that sudden and complete loss of balance-sense has persistent and complex effects on the way that rats navigate through and explore the environment.
Matthew Goddard; Yiwen Zheng; Cynthia L Darlington; Paul F Smith
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Behavioral neuroscience     Volume:  122     ISSN:  0735-7044     ISO Abbreviation:  Behav. Neurosci.     Publication Date:  2008 Apr 
Date Detail:
Created Date:  2008-04-15     Completed Date:  2008-06-03     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8302411     Medline TA:  Behav Neurosci     Country:  United States    
Other Details:
Languages:  eng     Pagination:  448-59     Citation Subset:  IM    
Department of Pharmacology and Toxicology, School of Medical Sciences, University of Otago , Dunedin, New Zealand.
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MeSH Terms
Adaptation, Physiological
Analysis of Variance
Exploratory Behavior / physiology*
Follow-Up Studies
Functional Laterality / physiology
Maze Learning / physiology*
Motor Activity / physiology*
Random Allocation
Rats, Wistar
Recovery of Function
Reflex, Vestibulo-Ocular / physiology*
Statistics, Nonparametric
Vestibule, Labyrinth / innervation,  physiology*

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