| Locked nucleic acid nucleoside triphosphates and polymerases: on the way towards evolution of LNA aptamers. | |
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MedLine Citation:
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PMID: 19603111 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Among numerous nucleic acid analogs reported in the past decades, locked nucleic acid (LNA) has received substantial attention and has become a significant tool within chemical biology disciplines like molecular biology research, diagnostics and therapeutic development. However, despite their obvious structurally unique properties, LNA-based aptamers for diagnostic and therapeutic applications remain largely unexplored. Future evolution of LNA oligonucleotide aptamers will depend on scientific breakthroughs relating to enzymatic polymerization using LNA nucleoside triphosphates as substrates. Herein, we highlight recent developments in this direction using various polymerases. |
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Authors:
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Rakesh N Veedu; Jesper Wengel |
Publication Detail:
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Type: Journal Article; Review Date: 2009-05-15 |
Journal Detail:
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Title: Molecular bioSystems Volume: 5 ISSN: 1742-2051 ISO Abbreviation: Mol Biosyst Publication Date: 2009 Aug |
Date Detail:
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Created Date: 2009-07-15 Completed Date: 2009-09-23 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 101251620 Medline TA: Mol Biosyst Country: England |
Other Details:
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Languages: eng Pagination: 787-92 Citation Subset: IM |
Affiliation:
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Department of Physics and Chemistry, Nucleic Acid Center, University of Southern Denmark, Campusvej 55, Odense M, Denmark. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Aptamers, Nucleotide
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chemical synthesis,
chemistry,
metabolism* DNA-Directed RNA Polymerases / metabolism* Models, Biological Oligonucleotides / chemical synthesis, chemistry, metabolism* |
| Chemical | |
Reg. No./Substance:
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0/Aptamers, Nucleotide; 0/Oligonucleotides; 0/locked nucleic acid; EC 2.7.7.6/DNA-Directed RNA Polymerases |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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