| Locked nucleic acid as a novel class of therapeutic agents. | |
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MedLine Citation:
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PMID: 19458498 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Locked Nucleic Acid (LNA) is a nucleic acid analogue with unprecedented binding affinity and excellent specificity toward complementary RNA and DNA oligonucleotides. The remarkable properties of LNA have led to applications within various gene silencing strategies both in vitro and in vivo. In the present review, we highlight the uses of LNA for regulation of gene expression with emphasis on RNA targeting. |
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Authors:
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Rakesh N Veedu; Jesper Wengel |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't; Review Date: 2009-07-18 |
Journal Detail:
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Title: RNA biology Volume: 6 ISSN: 1555-8584 ISO Abbreviation: RNA Biol Publication Date: 2009 Jul-Aug |
Date Detail:
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Created Date: 2009-08-28 Completed Date: 2009-11-04 Revised Date: 2011-07-08 |
Medline Journal Info:
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Nlm Unique ID: 101235328 Medline TA: RNA Biol Country: United States |
Other Details:
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Languages: eng Pagination: 321-3 Citation Subset: IM |
Affiliation:
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Nucleic Acid Center, Department of Physics and Chemistry, University of Southern Denmark, Odense, Denmark. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Aptamers, Nucleotide / genetics Gene Expression Regulation* Humans Oligonucleotides / chemistry, genetics*, therapeutic use* Oligonucleotides, Antisense / genetics RNA / genetics |
| Chemical | |
Reg. No./Substance:
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0/Aptamers, Nucleotide; 0/Oligonucleotides; 0/Oligonucleotides, Antisense; 0/locked nucleic acid; 63231-63-0/RNA |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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