| Locked nucleic acids: promising nucleic acid analogs for therapeutic applications. | |
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MedLine Citation:
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PMID: 20232325 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Locked Nucleic Acid (LNA) is a unique nucleic-acid modification possessing very high binding affinity and excellent specificity toward complementary RNA or DNA oligonucleotides. The remarkable properties exhibited by LNA oligonucleotides have been employed in different nucleic acid-based therapeutic strategies both in vitro and in vivo. Herein, we highlight the applications of LNA nucleotides for controlling gene expression. |
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Authors:
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Rakesh N Veedu; Jesper Wengel |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't; Review |
Journal Detail:
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Title: Chemistry & biodiversity Volume: 7 ISSN: 1612-1880 ISO Abbreviation: Chem. Biodivers. Publication Date: 2010 Mar |
Date Detail:
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Created Date: 2010-03-22 Completed Date: 2010-06-22 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 101197449 Medline TA: Chem Biodivers Country: Switzerland |
Other Details:
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Languages: eng Pagination: 536-42 Citation Subset: IM |
Affiliation:
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Nucleic Acid Center, Department of Physics and Chemistry, University of Southern Denmark, Campusvej 55, DK-5230 Odense M. rnv@ifk.sdu.dk |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Aptamers, Nucleotide
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chemistry DNA / chemistry DNA, Catalytic / chemistry, metabolism MicroRNAs / chemistry, metabolism Oligonucleotides / chemistry*, therapeutic use Oligonucleotides, Antisense / chemistry RNA, Complementary / chemistry RNA, Small Interfering / chemistry, metabolism |
| Chemical | |
Reg. No./Substance:
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0/Aptamers, Nucleotide; 0/DNA, Catalytic; 0/MicroRNAs; 0/Oligonucleotides; 0/Oligonucleotides, Antisense; 0/RNA, Complementary; 0/RNA, Small Interfering; 0/locked nucleic acid; 9007-49-2/DNA |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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