Document Detail


Location matters: synaptotagmin helps place vesicles near calcium channels.
MedLine Citation:
PMID:  19709623     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Positioning releasable vesicles near voltage-gated calcium channels may ensure transmitter release upon calcium influx. Disruption of vesicle positioning may underlie short-term synaptic depression. However, how this positioning is achieved is unclear. In this issue of Neuron, Young and Neher find that synaptotagmin 2 helps to align readily releasable vesicles near calcium channels at nerve terminals.
Authors:
Benjamin D McNeil; Ling-Gang Wu
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Publication Detail:
Type:  Comment; Journal Article; Review    
Journal Detail:
Title:  Neuron     Volume:  63     ISSN:  1097-4199     ISO Abbreviation:  Neuron     Publication Date:  2009 Aug 
Date Detail:
Created Date:  2009-08-27     Completed Date:  2009-09-21     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8809320     Medline TA:  Neuron     Country:  United States    
Other Details:
Languages:  eng     Pagination:  419-21     Citation Subset:  IM    
Affiliation:
National Institute of Neurological Disorders and Stroke, Bethesda, MD 20892, USA.
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MeSH Terms
Descriptor/Qualifier:
Animals
Calcium Channels / chemistry,  metabolism*,  physiology
Cell Communication / genetics,  physiology*
Humans
Multigene Family / physiology
Presynaptic Terminals / chemistry,  metabolism,  physiology
Synaptic Transmission / physiology*
Synaptic Vesicles / chemistry,  metabolism*,  physiology
Synaptotagmins / physiology*
Chemical
Reg. No./Substance:
0/Calcium Channels; 134193-27-4/Synaptotagmins
Comments/Corrections
Comment On:
Neuron. 2009 Aug 27;63(4):482-96   [PMID:  19709630 ]

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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