Document Detail

Location of flow limitation in liquid-filled rabbit lungs.
MedLine Citation:
PMID:  16340368     Owner:  NLM     Status:  MEDLINE    
The effects of end-inspiratory lung volume (EILV) and expiratory flow rate (Q) on the location of flow limitation in liquid-filled lungs were investigated by measuring pressure along the airways and by radiographic imaging. The lungs of New Zealand white rabbits were filled with perfluorocarbon to the randomly selected EILV of 20, 30, or 40 ml/kg, and the volume was actively drained at one of three Q: 2.5, 5.0, or 7.5 ml/s. The minimum pressures recorded by a movable catheter at locations along the airways show that flow limitation occurred in the main bronchi and trachea, and was independent of EILV and Q. The minimum pressure at the trachea was -80 mm Hg compared with values that were more positive than -10 mm Hg at a location 3 cm distal to the carina for all EILV and Q combinations. This location was confirmed by the lung images. The airway diameters gradually decreased with time, until flow limitation occurred. In airways distal to the collapse, there was not a significant decrease in diameter. Based on these data, we conclude that flow limitation in liquid-filled lungs occurs in the trachea and main bronchi and its location is independent of EILV or Q.
Joseph L Bull; David S Foley; Paola Bagnoli; Stefano Tredici; David O Brant; Ronald B Hirschl
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.    
Journal Detail:
Title:  ASAIO journal (American Society for Artificial Internal Organs : 1992)     Volume:  51     ISSN:  1058-2916     ISO Abbreviation:  ASAIO J.     Publication Date:    2005 Nov-Dec
Date Detail:
Created Date:  2005-12-12     Completed Date:  2006-03-02     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  9204109     Medline TA:  ASAIO J     Country:  United States    
Other Details:
Languages:  eng     Pagination:  781-8     Citation Subset:  IM    
Biomedical Engineering Department, The University of Michigan, Ann Arbor, MI 48109, USA.
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MeSH Terms
Biomedical Engineering
Forced Expiratory Flow Rates / physiology
Inspiratory Capacity / physiology
Liquid Ventilation*
Lung / physiology*,  radiography
Respiratory Mechanics
Grant Support

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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