Document Detail

Location of acute brain hemorrhage in patients undergoing antithrombotic therapy.
MedLine Citation:
PMID:  19254798     Owner:  NLM     Status:  MEDLINE    
INTRODUCTION: The relationship between antithrombotic therapy and the anatomical location of acute brain hematoma remains disputed. The current study was therefore designed to address this issue. METHODS: The medical records and CT images were retrospectively reviewed in 484 consecutive patients with an acute brain hemorrhage (291 men, 193 women; mean age, 67.2+/-12.3 years) who were admitted to the hospital within 7 days of stroke onset from January 1999 through October 2003. Antithrombotic therapy had been performed in 116 patients (AT Group): warfarin (n=38), antiplatelet therapy (n=70), or both (n=8). The other 368 patients had not received antithrombotic therapy (non-AT Group). The hematoma location was compared among the groups. RESULTS: The location of the hematoma was significantly different between the two groups (p<0.0001). The following locations were seen more frequently in the AT Group than in the non-AT Group: thalamic hemorrhage (44.8% vs. 30.7%), cerebellar hemorrhage (7.8% vs. 2.7%), and lobar hemorrhage (18.1% vs. 11.4%). The clinical characteristics in patients with thalamic, cerebellar, or lobar hemorrhage were compared with those with putaminal hemorrhage. A multivariate analysis using the logistic regression model showed that antithrombotic therapy was an independent factor for cerebellar hemorrhage (OR 3.66, 95%CI 1.31-10.18), lobar hemorrhage (OR 2.27, 95%CI 1.12-4.57), and thalamic hemorrhage (OR 2.20, 95%CI 1.06-4.54) in comparison to putaminal hemorrhage. CONCLUSIONS: It therefore appears that antithrombotic therapy is independently associated with thalamic, cerebellar, and lobar hemorrhage.
Ryo Itabashi; Masahiro Yasaka; Takahiro Kuwashiro; Hideaki Nakagaki; Fumio Miyashita; Hiroaki Naritomi; Kazuo Minematsu
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Publication Detail:
Type:  Journal Article     Date:  2009-02-28
Journal Detail:
Title:  Journal of the neurological sciences     Volume:  280     ISSN:  1878-5883     ISO Abbreviation:  J. Neurol. Sci.     Publication Date:  2009 May 
Date Detail:
Created Date:  2009-04-06     Completed Date:  2009-08-10     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0375403     Medline TA:  J Neurol Sci     Country:  Netherlands    
Other Details:
Languages:  eng     Pagination:  87-9     Citation Subset:  IM    
Cerebrovascular Division, Department of Medicine, National Cardiovascular Center, 5-7-1 Fujishirodai, Suita, Osaka, Japan.
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MeSH Terms
Brain / drug effects,  pathology
Fibrinolytic Agents / therapeutic use*
Intracranial Hemorrhages / drug therapy*,  pathology*
Logistic Models
Multivariate Analysis
Platelet Aggregation Inhibitors / therapeutic use*
Risk Factors
Tomography, X-Ray Computed
Warfarin / therapeutic use*
Reg. No./Substance:
0/Fibrinolytic Agents; 0/Platelet Aggregation Inhibitors; 81-81-2/Warfarin

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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